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Blood, 1 November 2006, Vol. 108, No. 9, pp. 3053-3060. Prepublished online as a Blood First Edition Paper on July 6, 2006; DOI 10.1182/blood-2006-05-020495. This Article Full Text (PDF) All Versions of this Article: blood-2006-05-020495v1 108/9/3053    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Hoffman, M. Articles by Monroe, D. M Search for Related Content PubMed PubMed Citation Articles by Hoffman, M. Articles by Monroe, D. M Related Collections Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted May 1, 2006 Accepted June 24, 2006 Cutaneous wound healing is impaired in hemophilia B Maureane Hoffman*, Anna Harger, Angela Lenkowski, Ulla Hedner, Harold R. Roberts, and Dougald M Monroe Durham VA Medical Center Duke University Novonordisk A/S UNC School of Medicine UNC Chapel Hill * Corresponding author; email: maureane{at}med.unc.edu. We used a mouse model to test the hypothesis that the time course and histology of wound healing is altered in hemophilia B. Three mm punch biopsies were placed in the skin of normal and hemophilic mice. The size of the wounds was measured daily until the epidermal defect closed. All wounds closed in hemophilic mice by 12 days, compared to 10 days in normal animals. Skin from the area of the wound was harvested at different time points and examined histologically. Hemophilic, but not normal animals, developed subcutaneous hematomas. Macrophage infiltration was significantly delayed in hemophilia B. Unexpectedly, hemophilic mice developed twice as many blood vessels in the healing wounds as controls, and the increased vascularity persisted for at least two weeks. The deposition and persistence of ferric iron was also greater in hemophilic mice. We hypothesize that iron plays a role in promoting excess angiogenesis after wounding as it had been proposed to do in hemophilic arthropathy. We have demonstrated that impaired coagulation leads to delayed wound healing with abnormal histology. Our findings have significant implications for treatment of hemophiliacs, and also highlight the importance of rapidly establishing hemostasis following trauma or surgery. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: Heavy metal FIX for Christmas wounds Leonard A. Valentino Blood 2006 108: 2888. [Full Text] [PDF] This article has been cited by other articles: T. Orfeo, K. E. Brummel-Ziedins, M. Gissel, S. Butenas, and K. G. Mann The Nature of the Stable Blood Clot Procoagulant Activities J. Biol. Chem., April 11, 2008; 283(15): 9776 - 9786. [Abstract] [Full Text] [PDF] A. G. McDonald, K. Yang, H. R. Roberts, D. M. Monroe, and M. Hoffman Perivascular tissue factor is down-regulated following cutaneous wounding: implications for bleeding in hemophilia Blood, February 15, 2008; 111(4): 2046 - 2048. [Abstract] [Full Text] [PDF] Y. Zheng, M. Watanabe, T. Kuraishi, S. Hattori, C. Kai, and M. Shibuya Chimeric VEGF-ENZ7/PlGF Specifically Binding to VEGFR-2 Accelerates Skin Wound Healing via Enhancement of Neovascularization Arterioscler. Thromb. Vasc. Biol., March 1, 2007; 27(3): 503 - 511. [Abstract] [Full Text] [PDF]

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