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Blood, 15 January 2007, Vol. 109, No. 2, pp. 693-702. Prepublished online as a Blood First Edition Paper on September 19, 2006; DOI 10.1182/blood-2006-05-020800. This Article Full Text (PDF) Supplemental Table and Figure All Versions of this Article: blood-2006-05-020800v1 109/2/693    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Ame-Thomas, P. Articles by Tarte, K. Search for Related Content PubMed PubMed Citation Articles by Ame-Thomas, P. Articles by Tarte, K. Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted May 2, 2006 Accepted August 29, 2006 Human mesenchymal stem cells isolated from bone marrow and lymphoid organs support tumor B-cell growth: Role of stromal cells in follicular lymphoma pathogenesis Patricia Ame-Thomas, Helene Maby-El Hajjami, Celine Monvoisin, Rachel Jean, Delphine Monnier, Sylvie Caulet-Maugendre, Thierry Guillaudeux, Thierry Lamy, Thierry Fest, and Karin Tarte* Faculte de Medecine, University Rennes, Rennes, France UF SITI, Departement HITC, CHU Pontchaillou, Rennes, France Laboratoire d'Anatomie Pathologique, CHU Pontchaillou, Rennes, France Service d'Hematologie Clinique, CHU Pontchaillou, Rennes, France * Corresponding author; email: karin.tarte{at}univ-rennes1.fr. There is accumulating evidence that cellular microenvironment plays a key role in follicular lymphoma (FL) pathogenesis, both within tumor lymph nodes and in infiltrated bone marrow where ectopic lymph node-like reticular cells are integrated within malignant B-cell nodular aggregates. In normal secondary lymphoid organs, specific stromal cell subsets provide a highly specialized microenvironment that supports immune response. In particular, fibroblastic reticular cells (FRC) mediate immune cell migration, adhesion, and reciprocal interactions. The role of FRC and their postulated progenitors, i.e. bone marrow mesenchymal stem cells (MSC), in FL remains unexplored. In this study, we have investigated the relationships between FRC and MSC and their capacity to sustain malignant B-cell growth. Our findings strongly suggest that secondary lymphoid organs contain MSC able to give rise to adipocytes, chondrocytes, osteoblasts, as well as fully functional B-cell supportive FRC. Bone marrow-derived MSC acquire in vitro a complete FRC phenotype in response to a combination of tumor necrosis factor- and lymphotoxin-12. Moreover, MSC recruit primary FL cells that, in turn, trigger their differentiation into FRC, making them able to support malignant B-cell survival. Altogether, these new insights into the crosstalk between lymphoma cells and their microenvironment could offer original therapeutic strategies. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: M. Travert, P. Ame-Thomas, C. Pangault, A. Morizot, O. Micheau, G. Semana, T. Lamy, T. Fest, K. Tarte, and T. Guillaudeux CD40 Ligand Protects from TRAIL-Induced Apoptosis in Follicular Lymphomas through NF-{kappa}B Activation and Up-Regulation of c-FLIP and Bcl-xL J. Immunol., July 15, 2008; 181(2): 1001 - 1011. [Abstract] [Full Text] [PDF]

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