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Blood, 1 January 2007, Vol. 109, No. 1, pp. 185-193. Prepublished online as a Blood First Edition Paper on September 7, 2006; DOI 10.1182/blood-2006-05-022954. This Article Full Text (PDF) All Versions of this Article: blood-2006-05-022954v1 109/1/185    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Jorgl, A. Articles by Strobl, H. Search for Related Content PubMed PubMed Citation Articles by Jorgl, A. Articles by Strobl, H. Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted May 11, 2006 Accepted August 14, 2006 Human Langerhans cell activation triggered in vitro by conditionally expressed MKK6 is counter-regulated by the downstream effector RelB Almut Jorgl, Barbara Platzer, Sabine Taschner, Leonhard X. Heinz, Bernhard Hocher, Peter M. Reisner, Florian Gobel, and Herbert Strobl* Institute of Immunology, Medical University Vienna Department of Biochemistry, University of Lausanne * Corresponding author; email: herbert.strobl{at}meduniwien.ac.at. Environmentally exposed epithelial Langerhans cells (LCs) encounter diverse innate stress signals, which lead to the activation of complex intracellular signaling cascades. Among these, p38 MAPK is consistently phosphorylated. For which aspects of LC activation triggering of p38 signaling is sufficient remains to be elucidated. We show that conditional induction of a dominant active form of MAPK kinase 6 (d.a.MKK6), a direct upstream kinase of p38, in LCs efficiently induces the upregulation of co-stimulatory molecules and enhances their T cell stimulatory capacity. These immediate effects showed no or only a minor requirement for classical NF-B signaling. Concomitant with LC activation, d.a.MKK6 induced the alternative NF-B member RelB, whose nuclear localization marks mature DCs. Specific inhibition of nuclear RelB during d.a.MKK6-induced LC activation further enhanced their maturation state. This observation was validated using the p38 activator anisomycin thus suggesting a novel LC intrinsic control mechanism regulated by RelB. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: F. Gobel, S. Taschner, J. Jurkin, S. Konradi, C. Vaculik, S. Richter, D. Kneidinger, C. Muhlbacher, C. Bieglmayer, A. Elbe-Burger, et al. Reciprocal role of GATA-1 and vitamin D receptor in human myeloid dendritic cell differentiation Blood, October 29, 2009; 114(18): 3813 - 3821. [Abstract] [Full Text] [PDF] B. Platzer, S. Richter, D. Kneidinger, D. Waltenberger, M. Woisetschlager, and H. Strobl Aryl Hydrocarbon Receptor Activation Inhibits In Vitro Differentiation of Human Monocytes and Langerhans Dendritic Cells J. Immunol., July 1, 2009; 183(1): 66 - 74. [Abstract] [Full Text] [PDF] S. J. A. M. Santegoets, A. J. M. van den Eertwegh, A. A. van de Loosdrecht, R. J. Scheper, and T. D. de Gruijl Human dendritic cell line models for DC differentiation and clinical DC vaccination studies J. Leukoc. Biol., December 1, 2008; 84(6): 1364 - 1373. [Abstract] [Full Text] [PDF]

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