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Blood, 1 February 2007, Vol. 109, No. 3, pp. 1069-1076. Prepublished online as a Blood First Edition Paper on September 26, 2006; DOI 10.1182/blood-2006-05-024364. This Article Full Text (PDF) All Versions of this Article: blood-2006-05-024364v1 109/3/1069    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Pandrea, I. Articles by Silvestri, G. Search for Related Content PubMed PubMed Citation Articles by Pandrea, I. Articles by Silvestri, G. Related Collections Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted May 18, 2006 Accepted September 14, 2006 Paucity of CD4+CCR5+ T-cells is a typical feature of natural SIV hosts Ivona Pandrea*, Cristian Apetrei, Shari N Gordon, Joseph Barbercheck, Jason Dufour, Rudolf Bohm, Beth S Sumpter, Pierre Roques, Preston A Marx, Vanessa M Hirsch, Amitinder Kaur, Andrew A Lackner, Ronad S Veazey, and Guido Silvestri Tulane National Primate Research Center, Covington, LA Yerkes National Primate Research Center, Atlanta, GA, Centre International de Recherches Medicales, Franceville, Gabon Laboratory of Molecular Microbiology, NIAID, NIH, Bethesda, MD New England Primate Research Center, Southborough, MA Department of Pathology, University of Pennsylvania, Philadelphia, PA * Corresponding author; email: ipandrea{at}tulane.edu. In contrast to lentiviral infections of humans and macaques, SIV infection of natural hosts is non-pathogenic despite high levels of viral replication. However, the mechanisms underlying this absence of disease are unknown. Here we report that natural hosts for SIV infection express remarkably low levels of CCR5 on CD4+ T-cells isolated from blood, lymph nodes, and mucosal tissues. As this immunological feature is found in five different species of natural SIV hosts (sooty mangabeys, African green monkeys, mandrills, sun-tailed monkeys, and chimpanzes) but absent in four non-natural/recent hosts (humans, rhesus, pigtail, cynomolgous macaques, and baboons), it may represent a key feature of the co-evolution between the virus and its natural hosts that led to a non-pathogenic infection. Beneficial effects of low CCR5 expression on CD4+ T-cells may include the reduction of target cells for viral replication and/or a decreased homing of activated CD4+ T-cells to inflamed tissue. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: CCR5 and HIV: the less, the better Mario Roederer and Joseph Mattapallil Blood 2007 109: 854. [Full Text] [PDF] This article has been cited by other articles: I. Pandrea, R. Onanga, S. Souquiere, A. Mouinga-Ondeme, O. Bourry, M. Makuwa, P. Rouquet, G. Silvestri, F. Simon, P. Roques, et al. Paucity of CD4+ CCR5+ T Cells May Prevent Transmission of Simian Immunodeficiency Virus in Natural Nonhuman Primate Hosts by Breast-Feeding J. Virol., June 1, 2008; 82(11): 5501 - 5509. [Abstract] [Full Text] [PDF] I. Pandrea, R. M. Ribeiro, R. Gautam, T. Gaufin, M. Pattison, M. Barnes, C. Monjure, C. Stoulig, J. Dufour, W. Cyprian, et al. Simian Immunodeficiency Virus SIVagm Dynamics in African Green Monkeys J. Virol., April 1, 2008; 82(7): 3713 - 3724. [Abstract] [Full Text] [PDF] S. N. Gordon, R. M. Dunham, J. C. Engram, J. Estes, Z. Wang, N. R. Klatt, M. Paiardini, I. V. Pandrea, C. Apetrei, D. L. Sodora, et al. Short-Lived Infected Cells Support Virus Replication in Sooty Mangabeys Naturally Infected with Simian Immunodeficiency Virus: Implications for AIDS Pathogenesis J. Virol., April 1, 2008; 82(7): 3725 - 3735. [Abstract] [Full Text] [PDF] V. Monceaux, L. Viollet, F. Petit, M. C. Cumont, G. R. Kaufmann, A. M. Aubertin, B. Hurtrel, G. Silvestri, and J. Estaquier CD4+ CCR5+ T-Cell Dynamics during Simian Immunodeficiency Virus Infection of Chinese Rhesus Macaques J. Virol., December 15, 2007; 81(24): 13865 - 13875. [Abstract] [Full Text] [PDF] S. N. Gordon, N. R. Klatt, S. E. Bosinger, J. M. Brenchley, J. M. Milush, J. C. Engram, R. M. Dunham, M. Paiardini, S. Klucking, A. Danesh, et al. Severe Depletion of Mucosal CD4+ T Cells in AIDS-Free Simian Immunodeficiency Virus-Infected Sooty Mangabeys J. Immunol., September 1, 2007; 179(5): 3026 - 3034. [Abstract] [Full Text] [PDF] I. V. Pandrea, R. Gautam, R. M. Ribeiro, J. M. Brenchley, I. F. Butler, M. Pattison, T. Rasmussen, P. A. Marx, G. Silvestri, A. A. Lackner, et al. Acute Loss of Intestinal CD4+ T Cells Is Not Predictive of Simian Immunodeficiency Virus Virulence J. Immunol., September 1, 2007; 179(5): 3035 - 3046. [Abstract] [Full Text] [PDF] S. Mummidi, L. M. Adams, S. E. VanCompernolle, M. Kalkonde, J. F. Camargo, H. Kulkarni, A. S. Bellinger, G. Bonello, H. Tagoh, S. S. Ahuja, et al. Production of Specific mRNA Transcripts, Usage of an Alternate Promoter, and Octamer-Binding Transcription Factors Influence the Surface Expression Levels of the HIV Coreceptor CCR5 on Primary T Cells J. Immunol., May 1, 2007; 178(9): 5668 - 5681. [Abstract] [Full Text] [PDF]

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