Blood online
Home About Blood Authors Subscriptions Permission Advertising Public Access contact us
 

 
Advanced
Current Issue
First Edition
Archives
Submit to Blood
Search
American Society of Hematology
Meeting Abstracts
Email Alerts
Blood, 1 November 2006, Vol. 108, No. 9, pp. 3005-3011.
Prepublished online as a Blood First Edition Paper on July 6, 2006; DOI 10.1182/blood-2006-05-024430.


This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
blood-2006-05-024430v1
108/9/3005    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Right arrow Rights and Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Chou, W.-C.
Right arrow Articles by Lee, C.-K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Chou, W.-C.
Right arrow Articles by Lee, C.-K.
Social Bookmarking
 Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

arrow to previous article Previous Article  |  Next Article next article arrow

Submitted May 22, 2006
Accepted June 18, 2006

STAT3 positively regulates an early step in B-cell development

Wei-Chun Chou, David E. Levy, and Chien-Kuo Lee*

Graduate Institute of Immunology, National Taiwan University College of Medicine
Departments of Pathology and Microbiology, New York University School of Medicine

* Corresponding author; email: leeck{at}ha.mc.ntu.edu.tw.

Transcription factors are critical for instructing the development of B lymphocytes from multipotential progenitor cells in the bone marrow (BM). Here, we showed that absence of STAT3 impaired B cell development. Mice selectively lacking STAT3 in BM progenitor cells displayed reduced numbers of mature B cells, both in the BM and periphery. The reduction in the B cell compartment included a reduced percentage and number of pro-B, pre-B, and immature B cells in the absence of STAT3, while the number of pre-pro-B cells was increased. We found that pro-B and pre-B cell populations lacking STAT3 were hyporesponsive to IL-7, due to a decreased number of IL-7 responsive cells rather than to decreased expression or signaling of IL-7R{alpha}. Moreover, STAT3-deficient mice displayed enhanced apoptosis in the pro-B population when deprived of survival factors, suggesting that at least two mechanisms (impaired differentiation and enhanced apoptosis) are involved in the mutant phenotype. Lastly, BM transplantation confirmed that impaired B lymphopoiesis in the absence of STAT3 was due to a cell autonomous defect. In sum, these studies defined a specific role for STAT3 in early B cell development, probably acting at the pre-pro B transition by contributing to the survival of IL-7 responsive progenitors.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
BloodHome page
J. Seita, M. Asakawa, J. Ooehara, S.-i. Takayanagi, Y. Morita, N. Watanabe, K. Fujita, M. Kudo, J. Mizuguchi, H. Ema, et al.
Interleukin-27 directly induces differentiation in hematopoietic stem cells
Blood, February 15, 2008; 111(4): 1903 - 1912.
[Abstract] [Full Text] [PDF]



 click for free articles
home about blood authors subscriptions permissions advertising public access contact us
  Copyright © 2006 by American Society of Hematology         Online ISSN: 1528-0020