SEARCH:   Advanced

Blood, 15 November 2006, Vol. 108, No. 10, pp. 3573-3579. Prepublished online as a Blood First Edition Paper on July 18, 2006; DOI 10.1182/blood-2006-05-024539. This Article Full Text (PDF) All Versions of this Article: blood-2006-05-024539v1 108/10/3573    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Vidarsson, G. Articles by van de Winkel, J. G Search for Related Content PubMed PubMed Citation Articles by Vidarsson, G. Articles by van de Winkel, J. G Related Collections Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted December 16, 2005 Accepted July 5, 2006 FcRn: an IgG receptor on phagocytes with a novel role in phagocytosis Gestur Vidarsson*, Annette M Stemerding, Nigel M Stapleton, Suzanne E Spliethoff, Hans Janssen, Frank E Rebers, Masja de Haas, and Jan G van de Winkel Immunotherapy Laboratory, Dept of Immunology, University Medical Center, Utrecht, The Netherlands Dept. Experimental Immunohematology, Sanquin Research, & Landsteiner Lab., University of Amsterdam Division of Cell Biology, Netherlands Cancer Institute, Amsterdam, The Netherlands * Corresponding author; email: g.vidarsson{at}sanquin.nl. Here, we report that the MHC class I related neonatal Fc receptor (FcRn) is expressed within azurophilic and specific granules of neutrophils, and relocates to phagolysosomes upon phagocytosis of IgG-opsonized bacteria. We found FcRn to enhance phagocytosis in a pH dependent manner which was independent of IgG recycling. IgG-opsonized bacteria were inefficiently phagocytosed by neutrophils from 2M knock-out or FcRn -chain knock-out mice, which both lack expression of FcRn. Similarly, low phagocytic activity was also observed with mutated IgG (H435A), which is incapable of binding to FcRn, while retaining normal binding to classical leukocyte Fc Receptors. Finally, a TAT peptide representing intracellular endocytosis- and transport motifs within FcRn, strongly inhibited IgG-mediated phagocytosis. These findings support a novel concept in which FcRn fulfills a major role in IgG-mediated phagocytosis. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: Tickle my innards Gregory P. Downey Blood 2006 108: 3230-3231. [Full Text] [PDF] This article has been cited by other articles: H. P. Montoyo, C. Vaccaro, M. Hafner, R. J. Ober, W. Mueller, and E. S. Ward Conditional deletion of the MHC class I-related receptor FcRn reveals the sites of IgG homeostasis in mice PNAS, February 24, 2009; 106(8): 2788 - 2793. [Abstract] [Full Text] [PDF] A. L. Cogen and T. A. Moore {beta}2-Microglobulin-Dependent Bacterial Clearance and Survival during Murine Klebsiella pneumoniae Bacteremia Infect. Immun., January 1, 2009; 77(1): 360 - 366. [Abstract] [Full Text] [PDF] N. A. Goebl, C. M. Babbey, A. Datta-Mannan, D. R. Witcher, V. J. Wroblewski, and K. W. Dunn Neonatal Fc Receptor Mediates Internalization of Fc in Transfected Human Endothelial Cells Mol. Biol. Cell, December 1, 2008; 19(12): 5490 - 5505. [Abstract] [Full Text] [PDF] L. Ye, X. Liu, S. N. Rout, Z. Li, Y. Yan, L. Lu, T. Kamala, N. K. Nanda, W. Song, S. K. Samal, et al. The MHC Class II-Associated Invariant Chain Interacts with the Neonatal Fc{gamma} Receptor and Modulates Its Trafficking to Endosomal/Lysosomal Compartments J. Immunol., August 15, 2008; 181(4): 2572 - 2585. [Abstract] [Full Text] [PDF] S.-W. Qiao, K. Kobayashi, F.-E. Johansen, L. M. Sollid, J. T. Andersen, E. Milford, D. C. Roopenian, W. I. Lencer, and R. S. Blumberg Dependence of antibody-mediated presentation of antigen on FcRn PNAS, July 8, 2008; 105(27): 9337 - 9342. [Abstract] [Full Text] [PDF] X. Liu, L. Ye, Y. Bai, H. Mojidi, N. E. Simister, and X. Zhu Activation of the JAK/STAT-1 Signaling Pathway by IFN-{gamma} Can Down-Regulate Functional Expression of the MHC Class I-Related Neonatal Fc Receptor for IgG J. Immunol., July 1, 2008; 181(1): 449 - 463. [Abstract] [Full Text] [PDF] J. M. Beekman, C. E. van der Poel, J. A. van der Linden, D. L. C. van den Berg, P. V. E. van den Berghe, J. G. J. van de Winkel, and J. H. W. Leusen Filamin A Stabilizes Fc{gamma}RI Surface Expression and Prevents Its Lysosomal Routing J. Immunol., March 15, 2008; 180(6): 3938 - 3945. [Abstract] [Full Text] [PDF] S. Akilesh, G. J. Christianson, D. C. Roopenian, and A. S. Shaw Neonatal FcR Expression in Bone Marrow-Derived Cells Functions to Protect Serum IgG from Catabolism J. Immunol., October 1, 2007; 179(7): 4580 - 4588. [Abstract] [Full Text] [PDF] L. Liu, A. M. Garcia, H. Santoro, Y. Zhang, K. McDonnell, J. Dumont, and A. Bitonti Amelioration of Experimental Autoimmune Myasthenia Gravis in Rats by Neonatal FcR Blockade J. Immunol., April 15, 2007; 178(8): 5390 - 5398. [Abstract] [Full Text] [PDF] R. A. Clemens, L. E. Lenox, T. Kambayashi, N. Bezman, J. S. Maltzman, K. E. Nichols, and G. A. Koretzky Loss of SLP-76 Expression within Myeloid Cells Confers Resistance to Neutrophil-Mediated Tissue Damage while Maintaining Effective Bacterial Killing J. Immunol., April 1, 2007; 178(7): 4606 - 4614. [Abstract] [Full Text] [PDF]

	Copyright © 2006 by American Society of Hematology         Online ISSN: 1528-0020