Blood online
Home About Blood Authors Subscriptions Permission Advertising Public Access contact us
 

 
Advanced
Current Issue
First Edition
Archives
Submit to Blood
Search
American Society of Hematology
Meeting Abstracts
Email Alerts
Blood, 15 January 2007, Vol. 109, No. 2, pp. 613-615.
Prepublished online as a Blood First Edition Paper on September 21, 2006; DOI 10.1182/blood-2006-05-026401.


This Article
Right arrow Full Text (PDF)
Right arrow Supplemental Table, Figures, and Video
Right arrow All Versions of this Article:
blood-2006-05-026401v1
109/2/613    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Right arrow Rights and Permissions
Citing Articles
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Yano, K.
Right arrow Articles by Aird, W. C
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Yano, K.
Right arrow Articles by Aird, W. C
Social Bookmarking
 Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

arrow to previous article Previous Article  |  Next Article next article arrow

Submitted May 31, 2006
Accepted September 1, 2006

Phenotypic heterogeneity is an evolutionarily conserved feature of the endothelium

Kiichiro Yano, Daniel Gale, Steffen Massberg, Pavan K Cheruvu, Rita Monahan-Earley, Ellen S Morgan, David Haig, Ulrich H von Andrian, Ann M Dvorak, and William C Aird*

Beth Israel Deaconess Medical Center, Boston, MA
CBR Institute for Biomedical Research, Boston, MA
Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA

* Corresponding author; email: waird{at}bidmc.harvard.edu.

Mammalian endothelial cells (ECs) display marked phenotypic heterogeneity. Little is known about the evolutionary mechanisms underlying EC heterogeneity. The last common ancestor of hagfish and gnathostomes was also the last common ancestor of all extant vertebrates, which lived some time more than 500 million years ago. Features of ECs that are shared between hagfish and gnathostomes can be inferred to have already been present in this ancestral vertebrate. The goal of this study was to determine whether hagfish endothelium displays phenotypic heterogeneity. Electron microscopy of the aorta, dermis, heart, and liver revealed ultrastructural heterogeneity of the endothelium. Immunofluorescent studies demonstrated marked differences in lectin binding between vascular beds. Intravital microscopy of the dermis revealed histamine-induced adhesion of leukocytes in capillaries and post-capillary venules, but not arterioles. Together, these data suggest that structural, molecular and functional heterogeneity of the endothelium evolved as an early feature of this cell lineage.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?




 click for free articles
home about blood authors subscriptions permissions advertising public access contact us
  Copyright © 2006 by American Society of Hematology         Online ISSN: 1528-0020