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Blood, 1 April 2007, Vol. 109, No. 7, pp. 2982-2984. Prepublished online as a Blood First Edition Paper on December 5, 2006; DOI 10.1182/blood-2006-06-022178. This Article Full Text (PDF) Supplemental Table and Figure All Versions of this Article: blood-2006-06-022178v1 109/7/2982    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Kraft, A. R M Articles by Dittmer, U. Search for Related Content PubMed PubMed Citation Articles by Kraft, A. R M Articles by Dittmer, U. Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted June 12, 2006 Accepted November 18, 2006 CpG Oligodeoxynucleotides allow for effective adoptive T-cell therapy in chronic retroviral infection Anke R M Kraft, Frank Krux, Simone Schimmer, Claes Ohlen, Philip D. Greenberg, and Ulf Dittmer* Institute for Virology, University of Duisburg-Essen, Essen, Germany SAIC-Frederick, Inc. / NCI at Frederick, Frederick, MD University of Washington, Seattle, WA * Corresponding author; email: ulf.dittmer{at}uni-essen.de. Adoptive T-cell therapy in cancer or chronic viral infections is often impeded by the development of functional impairment of the transferred cells. To overcome this therapeutic limitation we combined adoptive transfer of naive, virus-specific CD8+ T-cell with immunostimulative CpG oligodeoxynucleotides (ODN) in mice chronically infected with Friend retrovirus. The CpG-ODN co-injection prevented the T-cells from developing functional defects in IFNgamma and granzyme production and degranulation of cytotoxic molecules. Thus, the transferred T-cells were able to reduce chronic viral loads when combined with CpG-ODN. This strategy provides a new approach for developing successful adoptive T-cell therapy against chronic infections. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: S. Balkow, F. Krux, K. Loser, J. U. Becker, S. Grabbe, and U. Dittmer Friend retrovirus infection of myeloid dendritic cells impairs maturation, prolongs contact to naive T cells, and favors expansion of regulatory T cells Blood, December 1, 2007; 110(12): 3949 - 3958. [Abstract] [Full Text] [PDF]

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