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Blood, 1 May 2007, Vol. 109, No. 9, pp. 3658-3666. Prepublished online as a Blood First Edition Paper on January 9, 2007; DOI 10.1182/blood-2006-06-025627. This Article Full Text (PDF) Supplemental Appendix All Versions of this Article: blood-2006-06-025627v1 109/9/3658    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Cornelissen, J. J. Articles by Lowenberg, B. Search for Related Content PubMed PubMed Citation Articles by Cornelissen, J. J. Articles by Lowenberg, B. Related Collections Related Articles in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted June 1, 2006 Accepted December 28, 2006 Myeloablative HLA-identical sibling stem cell transplantation in first remission acute myeloid leukemia in young and middle aged adults: benefits for whom? results of a HOVON/SAKK donor versus no donor analysis Jan J. Cornelissen*, Wim L.J. van Putten, Leo F. Verdonck, Matthias Theobald, Emanuel Jacky, Simon M.G. Daenen, Marinus van Marwijk Kooy, Pierre Wijermans, Harry Schouten, Peter C. Huijgens, Hans van der Lelie, Martin Fey, Augustin Ferrant, Johan Maertens, Alois Gratwohl, and Bob Lowenberg Erasmus University Medical Center, Rotterdam, Netherlands Johannes Gutenberg University, Mainz, Germany University Medical Center, Utrecht, Netherlands University Hospital, Zurich, Switzerland University Medical Center, Groningen, Netherlands Isala Klinieken, Zwolle, Netherlands Haga Hospital, Den Haag, Netherlands University Hospital, Maastricht, Netherlands VU Medical Center, Amsterdam, Netherlands Amsterdam Medical Center, Amsterdam, Netherlands University Hospital, Bern, Switzerland Cliniques Universitaires Saint-Luc, Brussels, Belgium University Hospital Gasthuisberg, Leuven, Belgium Kantonsspital, Basel, Switzerland * Corresponding author; email: j.cornelissen{at}erasmusmc.nl. The HOVON-SAKK collaborative study group evaluated outcome of patients (pts) with AML in first remission (CR1) entered in 3 consecutive studies according a donor versus no donor comparison. Between 1987 and 2004, 2287 pts were entered in these studies of whom 1032 pts (45%) without FAB M3 or t(15;17) were in CR1 after 2 cycles of chemotherapy, received consolidation treatment, and were younger than 55 years of age and therefore eligible for allo-SCT. An HLA-identical sibling donor was available for 326 pts (32%), while 599 pts (58%) lacked such a donor and information was not available in 107 pts. Compliance with allo-SCT was 82% (268 out of 326). Cumulative incidences of relapse were, respectively, 32% versus 59% for pts with versus those without a donor (P<0.001). Despite more treatment related mortality (TRM) in the donor group (21% versus 4%, P<0.001), disease free survival (DFS) appeared significantly better in the donor group (48% (±3) versus 37% (±2) in the no-donor group, P<0.001). Following risk-group analysis, DFS was significantly better for pts with a donor and an intermediate (P=0.01) or poor risk profile (P=0.003) and also better in pts younger than 40 years of age (P<0.001). We evaluated our results and those of the previous MRC, BGMT and EORTC studies in a meta-analysis, which revealed a significant benefit of 12% in overall survival (OS) by donor availability for all patients with AML in CR1 without a favorable cytogenetic profile. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Articles in Blood Online: HLA-identical sibling stem-cell transplantation in first-remission AML Sikander Ailawadhi and Swaminathan Padmanabhan Blood 2007 110: 4619. [Full Text] [PDF] Response: Allogeneic hematopoetic stem-cell transplantation in acute myeloid leukemia Jan J. Cornelissen, Wim van Putten, and Bob Löwenberg Blood 2007 110: 4619-4620. [Full Text] [PDF]

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