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Blood, 1 December 2006, Vol. 108, No. 12, pp. 3730-3735. Prepublished online as a Blood First Edition Paper on August 1, 2006; DOI 10.1182/blood-2006-06-028787. This Article Full Text (PDF) All Versions of this Article: blood-2006-06-028787v1 108/12/3730    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Pak, M. Articles by Rivera, S. Search for Related Content PubMed PubMed Citation Articles by Pak, M. Articles by Rivera, S. Related Collections Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted June 13, 2006 Accepted July 11, 2006 Suppression of hepcidin during anemia requires erythropoietic activity Mihwa Pak, Miguel A Lopez, Victroia Gabayan, Tomas Ganz, and Seth Rivera* David Geffen School of Medicine at the University of California, Los Angeles * Corresponding author; email: sethrivera{at}mednet.ucla.edu. Hepcidin, the principal iron regulatory hormone, regulates the absorption of iron from the diet and the mobilization of iron from stores. Previous studies indicated that hepcidin is suppressed during anemia, a response that would appropriately increase the absorption of iron and its release from stores. Indeed, in the mouse model, hepcidin-1 was suppressed after phlebotomy or erythropoietin administration but the suppression was reversed by inhibitors of erythropoiesis. The suppression of hepcidin necessary to match iron supply to erythropoietic demand thus requires increased erythropoiesis and is not directly mediated by anemia, tissue hypoxia or erythropoietin. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: It's hepcidin again, but is it the only master? Prem Ponka and Alex D. Sheftel Blood 2006 108: 3631-3632. [Full Text] [PDF] This article has been cited by other articles: H. P.E. Peters, C. M.M. Laarakkers, D. W. Swinkels, and J. F.M. Wetzels Serum hepcidin-25 levels in patients with chronic kidney disease are independent of glomerular filtration rate Nephrol. Dial. Transplant., October 23, 2009; (2009) gfp546v1. [Abstract] [Full Text] [PDF] B. Young and J. Zaritsky Hepcidin for Clinicians Clin. J. Am. Soc. Nephrol., August 1, 2009; 4(8): 1384 - 1387. [Abstract] [Full Text] [PDF] P. Robach, S. Recalcati, D. Girelli, C. Gelfi, N. J. Aachmann-Andersen, J. J. Thomsen, A. M. 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