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Blood, 1 March 2007, Vol. 109, No. 5, pp. 2078-2085. Prepublished online as a Blood First Edition Paper on September 14, 2006; DOI 10.1182/blood-2006-06-028985. This Article Full Text (PDF) All Versions of this Article: blood-2006-06-028985v1 109/5/2078    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Catellani, S. Articles by Zocchi, M. R. Search for Related Content PubMed PubMed Citation Articles by Catellani, S. Articles by Zocchi, M. R. Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted June 15, 2006 Accepted August 7, 2006 Expansion of V1 T lymphocytes producing IL-4 in low-grade non-Hodgkin lymphomas expressing UL-16 binding proteins Silvia Catellani, Alessandro Poggi*, Andrea Bruzzone, Patrizia Dadati, Jean Louis Ravetti, Marco Gobbi, and Maria Raffaella Zocchi Laboratory of Hematology, University of Genoa, Italy Laboratory of Experimental Oncology D, National Institute for Cancer Research, Genoa, Italy Department of Internal Medicin, University of Genoa, Italy Department of Pathology, San Martino Hospital, University of Genoa, Italy Laboratory of Clinical Hematology, University of Genoa, Italy Laboratory of Tumor Immunology, San Raffaele Scientific Institute, Milan, Italy * Corresponding author; email: alessandro.poggi{at}istge.it. Twentythree patients with low grade non Hodgkin lymphomas (NHL), 4 mantle (MT), 4 marginal zone (MZ), 15 follicular (FL) were analyzed, compared to 10 high risk (HR) B cell chronic lymphocytic leukemias (B-CLL) with lymph node involvement and to 4 diffuse large cell lymphomas (DLCL). A significant increase in circulating V1 T lymphocytes producing interleukin-4 (IL-4) was found in FL, MT and MZ NHL patients, at variance with DLCL and HR B-CLL. IL-4 was also detectable in the sera and lymph nodes of the same patients. In the majority of NHL (19/23) with increased circulating V1 T lymphocytes, B cells expressing the UL-16-binding proteins (ULBPs) ULBP2 or ULBP3 or both were found in peripheral blood, bone marrow and/or lymph nodes. Of note, in HR B-CLL or in DLCL, where leukemic cells were ULBPs negative, no V T cell increase was found. Moreover, V1 T lymphocytes from FL NHL patients proliferate in response to ULBP2+ and ULBP3+ lymphoma cells. Finally, patients with high expression of ULBPs, increased circulating V1 T lymphocytes and high levels of serum IL-4 showed stable disease in a one year follow up, at variance with patients with low circulating V T cells and undetectable IL-4 or ULBPs. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: Y. Kong, W. Cao, X. Xi, C. Ma, L. Cui, and W. He The NKG2D ligand ULBP4 binds to TCR{gamma}9/{delta}2 and induces cytotoxicity to tumor cells through both TCR{gamma}{delta} and NKG2D Blood, July 9, 2009; 114(2): 310 - 317. [Abstract] [Full Text] [PDF] M. Todaro, M. D'Asaro, N. Caccamo, F. Iovino, M. G. Francipane, S. Meraviglia, V. Orlando, C. La Mendola, G. Gulotta, A. Salerno, et al. Efficient Killing of Human Colon Cancer Stem Cells by {gamma}{delta} T Lymphocytes J. Immunol., June 1, 2009; 182(11): 7287 - 7296. [Abstract] [Full Text] [PDF] N. L. Bryant, C. Suarez-Cuervo, G. Y. Gillespie, J. M. Markert, L. B. Nabors, S. Meleth, R. D. Lopez, and L. S. Lamb Jr. Characterization and immunotherapeutic potential of {gamma}{delta} T-cells in patients with glioblastoma Neuro-oncol, January 1, 2009; 11(4): 357 - 367. [Abstract] [Full Text] [PDF]

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