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Blood, 15 February 2007, Vol. 109, No. 4, pp. 1355-1362. Prepublished online as a Blood First Edition Paper on September 28, 2006; DOI 10.1182/blood-2006-06-030858. This Article Full Text (PDF) All Versions of this Article: blood-2006-06-030858v1 109/4/1355    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Mullally, A. Articles by Ritz, J. Search for Related Content PubMed PubMed Citation Articles by Mullally, A. Articles by Ritz, J. Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted June 21, 2006 Accepted September 20, 2006 Beyond HLA: the significance of genomic variation for allogeneic hematopoietic stem cell transplantation Ann Mullally and Jerome Ritz* Department of Medical Oncology, Dana-Farber Cancer Institute * Corresponding author; email: jerome_ritz{at}dfci.harvard.edu. The last two years have seen much excitement in the field of genetics with the identification of a formerly unappreciated level of "structural variation" within the normal human genome. Genetic structural variants include deletions, duplications and inversions in addition to the recently discovered, copy number variants (CNVs). Single nucleotide polymorphisms (SNPs) are the most extensively evaluated variant within the genome to date. Combining our knowledge from these studies with our rapidly accumulating understanding of structural variants, it is apparent that the extent of genetic dissimilarity between any two individuals is considerable and much greater than that which was previously recognized. Clearly, this more diverse view of the genome has significant implications for allogeneic hematopoietic stem cell transplantation (HSCT), not least in the generation of transplant antigens but also in terms of individual susceptibility to transplant related toxicities. With advances in DNA sequencing technology we now have the capacity to perform genome-wide analysis in a high throughput fashion, permitting a detailed genetic analysis of patient and donor prior to transplantation. Understanding the significance of this additional genetic information and applying it in a clinically meaningful way will be one of the challenges faced by transplant clinicians in the future. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: C. J. Wu and J. Ritz Revealing Tumor Immunity after Hematopoietic Stem Cell Transplantation Clin. Cancer Res., July 15, 2009; 15(14): 4515 - 4517. [Abstract] [Full Text] [PDF] T. M. Cao, L. C. Lazzeroni, S. Tsai, W. W. Pang, A. Kao, N. J. Camp, A. Thomas, and J. A. Shizuru Identification of a Major Susceptibility Locus for Lethal Graft-versus-Host Disease in MHC-Matched Mice J. Immunol., July 1, 2009; 183(1): 462 - 469. [Abstract] [Full Text] [PDF] Y. Ofran and J. Ritz Targets of Tumor Immunity After Allogeneic Hematopoietic Stem Cell Transplantation Clin. Cancer Res., August 15, 2008; 14(16): 4997 - 4999. [Abstract] [Full Text] [PDF] S. S. Tykodi, N. Fujii, N. Vigneron, S. M. Lu, J. K. Mito, M. X. Miranda, J. Chou, L. N. Voong, J. A. Thompson, B. M. Sandmaier, et al. C19orf48 Encodes a Minor Histocompatibility Antigen Recognized by CD8+ Cytotoxic T Cells from Renal Cell Carcinoma Patients Clin. Cancer Res., August 15, 2008; 14(16): 5260 - 5269. [Abstract] [Full Text] [PDF] J. W. Chien, M. J. Boeckh, J. A. Hansen, and J. G. Clark Lipopolysaccharide binding protein promoter variants influence the risk for Gram-negative bacteremia and mortality after allogeneic hematopoietic cell transplantation Blood, February 15, 2008; 111(4): 2462 - 2469. [Abstract] [Full Text] [PDF]

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