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Blood, 1 April 2007, Vol. 109, No. 7, pp. 3080-3083. Prepublished online as a Blood First Edition Paper on December 14, 2006; DOI 10.1182/blood-2006-06-031096. This Article Full Text (PDF) All Versions of this Article: blood-2006-06-031096v1 109/7/3080    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Sala-Torra, O. Articles by Radich, J. P. Search for Related Content PubMed PubMed Citation Articles by Sala-Torra, O. Articles by Radich, J. P. Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted June 26, 2006 Accepted November 17, 2006 Connective tissue growth factor (CTGF) expression and outcome in adult patients with acute lymphoblastic leukemia Olga Sala-Torra*, Holly M. Gundacker, Derek L. Stirewalt, Paula A. Ladne, Era L. Pogosova-Agadjanyan, Marilyn L. Slovak, Cheryl L. Willman, Shelly Heimfeld, David H. Boldt, and Jerald P. Radich Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA Statistical Center, Southwest Oncology Group, Seattle, WA Division of Pathology, City of Hope National Medical Center, Duarte, CA Department of Pathology, University of New Mexico School of Medicine, Albuquerque, NM Medicine/Hematology, University of Texas Health Science Center, San Antonio, TX * Corresponding author; email: osala{at}fhcrc.org. We compared the gene expression profile of adult acute lymphoblastic leukemia (ALL) to normal hematopoietic and non-ALL samples using oligonucleotide arrays. Connective tissue growth factor (CTGF) was the highest over-expressed gene in B-cell ALL compared to the other groups, and displayed heterogeneous expression, suggesting it might have prognostic relevance. CTGF expression was examined by quantitative RT-PCR on 79 adult ALL specimens. CTGF expression levels were significantly increased in ALL cases with B-lineage (p=0.0001), unfavorable cytogenetics (p=0.0002), and blasts expressing CD34 (p<0.0001). In a multivariate proportional hazards model, higher CTGF expression levels corresponded to worsening of OS (hazard ratio=1.36, for each 10-fold increase in expression; p=0.019). Further studies are ongoing to confirm the prognostic value of CTGF expression in ALL and to investigate its role in normal and abnormal lymphocyte biology. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: H. Zhang, C.-Y. Liu, Z.-Y. Zha, B. Zhao, J. Yao, S. Zhao, Y. Xiong, Q.-Y. Lei, and K.-L. Guan TEAD Transcription Factors Mediate the Function of TAZ in Cell Growth and Epithelial-Mesenchymal Transition J. Biol. Chem., May 15, 2009; 284(20): 13355 - 13362. [Abstract] [Full Text] [PDF] K. L. Bennewith, X. Huang, C. M. Ham, E. E. Graves, J. T. Erler, N. Kambham, J. Feazell, G. P. Yang, A. Koong, and A. J. Giaccia The Role of Tumor Cell-Derived Connective Tissue Growth Factor (CTGF/CCN2) in Pancreatic Tumor Growth Cancer Res., February 1, 2009; 69(3): 775 - 784. [Abstract] [Full Text] [PDF] V. Pullarkat, M. L. Slovak, K. J. Kopecky, S. J. Forman, and F. R. Appelbaum Impact of cytogenetics on the outcome of adult acute lymphoblastic leukemia: results of Southwest Oncology Group 9400 study Blood, March 1, 2008; 111(5): 2563 - 2572. [Abstract] [Full Text] [PDF]

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