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Blood, 15 January 2007, Vol. 109, No. 2, pp. 670-673. Prepublished online as a Blood First Edition Paper on September 7, 2006; DOI 10.1182/blood-2006-07-036509. This Article Full Text (PDF) All Versions of this Article: blood-2006-07-036509v1 109/2/670    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Nolte-'t Hoen, E. Articles by Davis, D. Search for Related Content PubMed PubMed Citation Articles by Nolte-'t Hoen, E. Articles by Davis, D. Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted July 19, 2006 Accepted August 21, 2006 Increased surveillance of cells in mitosis by human NK cells suggests a novel strategy for limiting tumor growth and viral replication Esther Nolte-'t Hoen, Catarina Almeida, Nadia Cohen, Shlomo Nedvetzki, Helen Yarwood, and Daniel Davis* Division of Cell and Molecular Biology, Sir Alexander Fleming Building, Imperial College London, UK Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, UK * Corresponding author; email: d.davis{at}imperial.ac.uk. The threat from cancer cells is inherently linked to cell-cycle progression, and viral genomes commonly replicate, e.g. within episomes or proviruses, during mitosis. We report here that human NK cells bound cells in mitosis, and attacked pathogenic cells in mitosis, more effectively than the same cells in other stages of the cell-cycle. Thus, cells in mitosis warrant and undergo heightened surveillance; a novel strategy for immunological assessment of danger. Recognition of cells in mitosis involved ligation of activating NK cell receptors and binding to target cell hyaluronan, a component of the pericellular matrix known to be increased during mitosis. Direct interaction between activating NK cell receptors and hyaluronan is possible but other mechanisms consistent with our data are also discussed. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: H. El Costa, A. Casemayou, M. Aguerre-Girr, M. Rabot, A. Berrebi, O. Parant, M. Clouet-Delannoy, L. Lombardelli, N. Jabrane-Ferrat, D. Rukavina, et al. Critical and Differential Roles of NKp46- and NKp30-Activating Receptors Expressed by Uterine NK Cells in Early Pregnancy J. Immunol., September 1, 2008; 181(5): 3009 - 3017. [Abstract] [Full Text] [PDF]

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