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Blood, 15 March 2007, Vol. 109, No. 6, pp. 2545-2552. Prepublished online as a Blood First Edition Paper on November 28, 2006; DOI 10.1182/blood-2006-07-037150. This Article Full Text (PDF) All Versions of this Article: blood-2006-07-037150v1 109/6/2545    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Kolar, G. R Articles by Capra, J. D. Search for Related Content PubMed PubMed Citation Articles by Kolar, G. R Articles by Capra, J. D. Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted July 27, 2006 Accepted September 18, 2006 A novel human B cell subpopulation representing the initial population to express AID Grant R Kolar, Darshna Mehta, Rosana Pelayo, and J. Donald Capra* Program in Molecular Immunogenetics, Oklahoma Medical Research Foundation, Oklahoma City, OK, United States Program in Immunobiology & Cancer, Oklahoma Medical Research Foundation, Oklahoma City, OK, United States * Corresponding author; email: donald-capra{at}omrf.ouhsc.edu. We have identified a novel mature human B cell subpopulation in the human tonsil that has characteristics of both naive B cells and as well as germinal center B cells including the expression of activation induced cytidine deaminase (AID) which is essential for the process of immunoglobulin somatic hypermutation and class switch recombination. These cells are clearly somatically hypermutated albeit modestly. Their phenotype (IgD+CD38-CD23-FSChiCD7+) is unique and suggests they may be intermediate between both naive and germinal center cells. Morphologically they are also distinct from other B cell subpopulations. The evidence presented suggests these cells may be the founder cells of the germinal center reaction (a pro-GC cell) and may be the normal counterpart of mantle cell lymphoma. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: S. M. Jackson, N. Harp, D. Patel, J. Wulf, E. D. Spaeth, U. K. Dike, J. A. James, and J. D. Capra Key developmental transitions in human germinal center B cells are revealed by differential CD45RB expression Blood, April 23, 2009; 113(17): 3999 - 4007. [Abstract] [Full Text] [PDF] L. Le Pottier, V. Devauchelle, A. Fautrel, C. Daridon, A. Saraux, P. Youinou, and J.-O. Pers Ectopic Germinal Centers Are Rare in Sjogren's Syndrome Salivary Glands and Do Not Exclude Autoreactive B Cells J. Immunol., March 15, 2009; 182(6): 3540 - 3547. [Abstract] [Full Text] [PDF] J. R. Darce, B. K. Arendt, X. Wu, and D. F. Jelinek Regulated Expression of BAFF-Binding Receptors during Human B Cell Differentiation J. Immunol., December 1, 2007; 179(11): 7276 - 7286. [Abstract] [Full Text] [PDF] Y. Natkunam The Biology of the Germinal Center Hematology, January 1, 2007; 2007(1): 210 - 215. [Abstract] [Full Text] [PDF]

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