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Blood, 1 February 2007, Vol. 109, No. 3, pp. 1237-1240. Prepublished online as a Blood First Edition Paper on September 28, 2006; DOI 10.1182/blood-2006-07-037465. This Article Full Text (PDF) All Versions of this Article: blood-2006-07-037465v1 109/3/1237    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Walter, M. J Articles by Ley, T. J Search for Related Content PubMed PubMed Citation Articles by Walter, M. J Articles by Ley, T. J Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted July 28, 2006 Accepted September 17, 2006 Expression of a bcr-1 isoform of RAR-PML does not affect the penetrance of acute promyelocytic leukemia or the acquisition of an interstitial deletion on mouse chromosome 2 Matthew J Walter, Rhonda E Ries, Jon R Armstrong, John S Park, Elaine R Mardis, and Timothy J Ley* Washington University School of Medicine Siteman Cancer Center, Washington University School of Medicine * Corresponding author; email: tley{at}im.wustl.edu. Expression of a bcr-3 isoform of RAR-PML in mice expressing a bcr-1 isoform of PML-RAR is associated with increased penetrance of murine acute promyelocytic leukemia (APL), and the frequent acquisition of an interstitial deletion of one copy of mouse chromosome 2 (del(2)). To determine whether the isoform of RAR-PML is important for these effects, we created mice that expressed a bcr-1 isoform of RAR-PML. Co-expression with the bcr-1 isoform of PML-RAR did not increase the penetrance of APL (7/45 of animals developed APL with PML- RAR alone, vs. 12/44 with both transgenes, p=0.19). Furthermore, the frequency of del(2) in APL cells from doubly transgenic mice was not different from mice expressing PML-RAR alone (3/6 vs. 6/12 respectively, p=1.38, compared with 11/11 for mice co-expressing PML-RAR and a bcr-3 RAR-PML). The bcr-1 and bcr-3 isoforms of RAR-PML therefore have different biologic activities that may be relevant for the pathogenesis of murine APL. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: T. Kondo, A. Mori, S. Darmanin, S. Hashino, J. Tanaka, and M. Asaka The seventh pathogenic fusion gene FIP1L1-RARA was isolated from a t(4;17)-positive acute promyelocytic leukemia Haematologica, September 1, 2008; 93(9): 1414 - 1416. [Full Text] [PDF]

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