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Blood, 1 April 2007, Vol. 109, No. 7, pp. 2921-2927.
Prepublished online as a Blood First Edition Paper on November 28, 2006; DOI 10.1182/blood-2006-07-037739.
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Submitted July 25, 2006
Accepted November 19, 2006
Induction of Th2 type immunity in a mouse system reveals a novel immunoregulatory role of basophils
Keunhee Oh, Tao Shen, Graham Le Gros, and Booki Min*
Department of Immunology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH
Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD
Malaghan Institute of Medical Research, Wellington, New Zealand
* Corresponding author; email: minb{at}ccf.org.
While production of cytokines such as IL-12 by activated dendritic cells supports development of Th1 type immunity, a source of early IL-4 that is responsible for Th2 immunity is not well understood. We now show that coculture of basophils could promote a robust Th2 differentiation upon stimulation of naive CD4 T cells primarily via IL-4. Th2 promotion by basophils was also observed even when naive CD4 T cells were stimulated in Th1-promoting condition or when fully differentiated Th1 phenotype effector CD4 T cells were restimulated. IL-4-deficient basophils failed to induce Th2 differentiation, yet suppressed Th1 differentiation. It was subsequently revealed that the IL-4-deficient basophils must engage cell-to-cell contact in order to exert the inhibitory effect on Th1 differentiation. Stimulation of naive CD4 T cells within in vivo environment of increased basophil generation supported development of Th2 type immunity. Taken together, our results suggest that basophils may provide an important link for the development of Th2 immunity.
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