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Blood, 1 March 2007, Vol. 109, No. 5, pp. 1998-2000.
Prepublished online as a Blood First Edition Paper on October 19, 2006; DOI 10.1182/blood-2006-07-038166.
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Submitted July 28, 2006
Accepted October 13, 2006
ADAMTS13 and von Willebrand Factor and the risk of myocardial infarction in men
Chan K.N.K. Chion, Carine J.M. Doggen, James T.B. Crawley*, David A. Lane, and Frits R. Rosendaal
Imperial College London, United Kingdom
Leiden University Medical Center, Netherlands
* Corresponding author; email: j.crawley{at}imperial.ac.uk.
Von Willebrand factor (VWF) mediates the tethering/adhesion of platelets at sites of vascular injury. This function depends upon its multimeric size, which is controlled by ADAMTS13. We measured plasma ADAMTS13 and VWF antigen levels by ELISA in a large population-based case-control study (SMILE), consisting of 560 men with a first myocardial infarction (MI) and 646 control subjects. Although ABO blood groups influenced VWF levels, they had no influence, upon ADAMTS13. Furthermore, there was no relationship between plasma ADAMTS13 and VWF levels. Similar to VWF, the estimated risk of MI was increased for every quartile of ADAMTS13 when compared to the lowest quartile (odds ratio 1.5 to 1.6). If confirmed, the association of ADAMTS13 with MI may suggest an unexpected mechanistic action of ADAMTS13.
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