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 Blood, 1 June 2007, Vol. 109, No. 11, pp. 4786-4792.
Prepublished online as a Blood First Edition Paper on February 15, 2007; DOI 10.1182/blood-2006-07-038539.

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Submitted July 31, 2006
Accepted January 29, 2007

Moderation of the platelet releasate response by aspirin

Judith A Coppinger, Roisin I O'Connor, Kieran Wynne, Michelle Flanagan, Matthew Sullivan, Patricia B Maguire, Desmond J Fitzgerald, and Gerard Cagney*

Dept of Cell Biology, Scripps Research Institute, La Jolla, CA, United States
School of Biomolecular & Biomedical Science, Conway Institute, University College Dublin, Dublin, Republic of Ireland
School of Medicine & Medical Science, University College Dublin, Dublin, Republic of Ireland
Proteome Research Center, Conway Institute, University College Dublin, Dublin, Republic of Ireland

* Corresponding author; email: gerard.cagney{at}ucd.ie.

Modulation of the proteins released during activation is one mechanism whereby aspirin may influence platelet-mediated human disease. We investigated the effect of aspirin on the platelet releasate using mass spectrometry and found that different agonists evoked different releasate profiles, with aspirin having a general moderating effect on the amount of protein released regardless of the agonist. These observations were confirmed for several cytokines using an antibody array approach.


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