Blood online
Home About Blood Authors Subscriptions Permission Advertising Public Access contact us
 

 
Advanced
Current Issue
First Edition
Future Articles
Archives
Submit to Blood
Search
American Society of Hematology
Meeting Abstracts
Email Alerts
Blood, 1 May 2007, Vol. 109, No. 9, pp. 3625-3632.
Prepublished online as a Blood First Edition Paper on January 3, 2007; DOI 10.1182/blood-2006-08-038844.


This Article
Right arrow Full Text (PDF)
Right arrow Supplemental Figure
Right arrow All Versions of this Article:
blood-2006-08-038844v1
109/9/3625    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Right arrow Rights and Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Parolini, S.
Right arrow Articles by Sozzani, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Parolini, S.
Right arrow Articles by Sozzani, S.
Social Bookmarking
 Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

arrow to previous article Previous Article  |  Next Article next article arrow

Submitted August 1, 2006
Accepted December 22, 2006

The role of chemerin in the co-localization of NK and dendritic cell subsets into inflamed tissues

Silvia Parolini, Amerigo Santoro, Emanuela Marcenaro, Walter Luini, Luisa Massardi, Fabio Facchetti, David Communi, Marc Parmentier, Alessandra Majorana, Marina Sironi, Giovanna Tabellini, Alessandro Moretta, and Silvano Sozzani*

Section of Histology, University of Brescia, Brescia, Italy
Section of Pathology, University of Brescia, Brescia, Italy
Dipartimento di Medicina Sperimentale, and Centro di Eccellenza per le Ricerche Biomediche, University of Genoa, Genoa, Italy
Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
Section of General Pathology and Immunology, University of Brescia, Brescia, Italy
Institut de Recherche Interdisciplinaire en Biologie Humaine, et Moleculaire, Universite Libre de Bruxelles, Brussels, Belgium
Department of Dental Medicine, University of Brescia, Spedali Civili Brescia, Brescia, Italy
Istituto Clinico Humanitas, Rozzano, Italy

* Corresponding author; email: sozzani{at}med.unibs.it.

Chemerin is a chemotactic agonist recently identified as the ligand of ChemR23, a serpentine receptor expressed by mononuclear phagocytes and dendritic cells. This study shows that blood CD56lowCD16+ NK cells selectively express functional ChemR23, and that this receptor is co-expressed with CXCR1, the CXCL8 receptor, and the KIR receptors. In vitro culturing of NK cells with IL-2 and IL-15 induced a delayed and time-dependent down-regulation of ChemR23 that was associated with the inhibition of NK cell migration to chemerin. Biopsies obtained from oral lichen planus patients presented an infiltration of CD94+CD3-CD56+ NK cells that co-expressed ChemR23. The same biopsies were infiltrated by myeloid, DC-SIGN+ and plasmacytoid, CD123+BDCA2+, ChemR23+ dendritic cells that were occasionally associated with NK cells. In the same histological sections, chemerin was expressed by inflamed dermal endothelium. These findings propose a role for the ChemR23/chemerin axis in the recruitment of blood NK cells and strongly implicate chemerin as a key factor for the co-localization of NK cells and DC subsets in pathological peripheral tissues.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
Acta Biochim Biophys SinHome page
X.-Y. Du and L. L.K. Leung
Proteolytic regulatory mechanism of chemerin bioactivity
Acta Biochim Biophys Sin, December 1, 2009; 41(12): 973 - 979.
[Abstract] [Full Text] [PDF]


Home page
J. Immunol.Home page
S. Luangsay, V. Wittamer, B. Bondue, O. De Henau, L. Rouger, M. Brait, J.-D. Franssen, P. de Nadai, F. Huaux, and M. Parmentier
Mouse ChemR23 Is Expressed in Dendritic Cell Subsets and Macrophages, and Mediates an Anti-Inflammatory Activity of Chemerin in a Lung Disease Model
J. Immunol., November 15, 2009; 183(10): 6489 - 6499.
[Abstract] [Full Text] [PDF]


Home page
J. Immunol.Home page
K. L. Graham, B. A. Zabel, S. Loghavi, L. A. Zuniga, P. P. Ho, R. A. Sobel, and E. C. Butcher
Chemokine-Like Receptor-1 Expression by Central Nervous System-Infiltrating Leukocytes and Involvement in a Model of Autoimmune Demyelinating Disease
J. Immunol., November 15, 2009; 183(10): 6717 - 6723.
[Abstract] [Full Text] [PDF]


Home page
BloodHome page
E. Marcenaro, C. Cantoni, S. Pesce, C. Prato, D. Pende, S. Agaugue, L. Moretta, and A. Moretta
Uptake of CCR7 and acquisition of migratory properties by human KIR+ NK cells interacting with monocyte-derived DC or EBV cell lines: regulation by KIR/HLA-class I interaction
Blood, November 5, 2009; 114(19): 4108 - 4116.
[Abstract] [Full Text] [PDF]


Home page
J. Immunol.Home page
M. Kool, M. van Nimwegen, M. A. M. Willart, F. Muskens, L. Boon, J. J. Smit, A. Coyle, B. E. Clausen, H. C. Hoogsteden, B. N. Lambrecht, et al.
An Anti-Inflammatory Role for Plasmacytoid Dendritic Cells in Allergic Airway Inflammation
J. Immunol., July 15, 2009; 183(2): 1074 - 1082.
[Abstract] [Full Text] [PDF]


Home page
JEMHome page
C. Albanesi, C. Scarponi, S. Pallotta, R. Daniele, D. Bosisio, S. Madonna, P. Fortugno, S. Gonzalvo-Feo, J.-D. Franssen, M. Parmentier, et al.
Chemerin expression marks early psoriatic skin lesions and correlates with plasmacytoid dendritic cell recruitment
J. Exp. Med., January 16, 2009; 206(1): 249 - 258.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
X.-Y. Du, B. A. Zabel, T. Myles, S. J. Allen, T. M. Handel, P. P. Lee, E. C. Butcher, and L. L. Leung
Regulation of Chemerin Bioactivity by Plasma Carboxypeptidase N, Carboxypeptidase B (Activated Thrombin-activable Fibrinolysis Inhibitor), and Platelets
J. Biol. Chem., January 9, 2009; 284(2): 751 - 758.
[Abstract] [Full Text] [PDF]


Home page
J. Leukoc. Biol.Home page
A. Guillabert, V. Wittamer, B. Bondue, V. Godot, V. Imbault, M. Parmentier, and D. Communi
Role of neutrophil proteinase 3 and mast cell chymase in chemerin proteolytic regulation
J. Leukoc. Biol., December 1, 2008; 84(6): 1530 - 1538.
[Abstract] [Full Text] [PDF]


Home page
JEMHome page
B. A. Zabel, S. Nakae, L. Zuniga, J.-Y. Kim, T. Ohyama, C. Alt, J. Pan, H. Suto, D. Soler, S. J. Allen, et al.
Mast cell-expressed orphan receptor CCRL2 binds chemerin and is required for optimal induction of IgE-mediated passive cutaneous anaphylaxis
J. Exp. Med., September 29, 2008; 205(10): 2207 - 2220.
[Abstract] [Full Text] [PDF]


Home page
BloodHome page
S. Agaugue, E. Marcenaro, B. Ferranti, L. Moretta, and A. Moretta
Human natural killer cells exposed to IL-2, IL-12, IL-18, or IL-4 differently modulate priming of naive T cells by monocyte-derived dendritic cells
Blood, September 1, 2008; 112(5): 1776 - 1783.
[Abstract] [Full Text] [PDF]


Home page
BloodHome page
T. Tha-In, H. J. Metselaar, H. W. Tilanus, Z. M. A. Groothuismink, E. J. Kuipers, R. A. de Man, and J. Kwekkeboom
Intravenous immunoglobulins suppress T-cell priming by modulating the bidirectional interaction between dendritic cells and natural killer cells
Blood, November 1, 2007; 110(9): 3253 - 3262.
[Abstract] [Full Text] [PDF]



 click for free articles
home about blood authors subscriptions permissions advertising public access contact us
  Copyright © 2007 by American Society of Hematology         Online ISSN: 1528-0020