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Blood, 15 March 2007, Vol. 109, No. 6, pp. 2446-2452. Prepublished online as a Blood First Edition Paper on November 14, 2006; DOI 10.1182/blood-2006-08-042515. This Article Full Text (PDF) Supplemental Appendix All Versions of this Article: blood-2006-08-042515v1 109/6/2446    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Landolfi, R. Articles by Marchioli, R. Search for Related Content PubMed PubMed Citation Articles by Landolfi, R. Articles by Marchioli, R. Related Collections Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted August 22, 2006 Accepted October 30, 2006 Leukocytosis as a major thrombotic risk factor in patients with Polycythemia Vera Raffaele Landolfi*, Leonardo Di Gennaro, Tiziano Barbui, Valerio De Stefano, Guido Finazzi, RosaMaria Marfisi, Gianni Tognoni, and Roberto Marchioli Catholic University School of Medicine, Italy Ospedali Riuniti, Italy Consorzio Mario Negri Sud, Italy * Corresponding author; email: rlandolfi{at}rm.unicatt.it. In Polycythemia Vera vascular risk assessment is based on age and thrombotic history while the role of other potential predictors of this risk is still uncertain. Thus, we exploited the large database collected by the observational study of the European Collaboration on Low-dose Aspirin in Polycythemia Vera to investigate the association of hematological variables and cardiovascular risk factors with the thrombotic risk. Among 1,638 polycythemic patients followed for 2.7±1.3 years there were 205 thromboses. Subjects with hypertension had a mild non significant increase of the risk of arterial thrombosis while this risk was significantly increased by smoke (Hazard Ratio 1.90; 95% confidence interval 1.15 to 3.14; P=0.0120) . The time-dependent analysis adjusted for potential confounders showed that patients with white blood cell count above15,000x106/L, compared to those with white blood cell count below 10,000x106/L, had a significant increase of the risk of thrombosis (Hazard Ratio 1.71; 95% confidence interval 1.10 to 2.65; P=0.0171) mainly deriving from an increased risk of myocardial infarction (Hazard Ratio 2.84; 95% confidence interval 1.25 to 6.46; P=0.0127). Thus, leukocyte count may help defining the vascular risk of polycythemic subjects. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: The granulocyte connection in MPD-associated thrombosis Ayalew Tefferi Blood 2007 109: 2270-2271. [Full Text] [PDF] This article has been cited by other articles: A. Quintas-Cardama, H. Kantarjian, T. Manshouri, R. Luthra, Z. Estrov, S. Pierce, M. A. Richie, G. Borthakur, M. Konopleva, J. Cortes, et al. Pegylated Interferon Alfa-2a Yields High Rates of Hematologic and Molecular Response in Patients With Advanced Essential Thrombocythemia and Polycythemia Vera J. Clin. Oncol., November 10, 2009; 27(32): 5418 - 5424. [Abstract] [Full Text] [PDF] T. Barbui, A. Carobbio, A. Rambaldi, and G. Finazzi Perspectives on thrombosis in essential thrombocythemia and polycythemia vera: is leukocytosis a causative factor? Blood, July 23, 2009; 114(4): 759 - 763. [Abstract] [Full Text] [PDF] A. M. Vannucchi, P. Guglielmelli, and A. Tefferi Advances in Understanding and Management of Myeloproliferative Neoplasms CA Cancer J Clin, May 1, 2009; 59(3): 171 - 191. [Abstract] [Full Text] [PDF] J. Malysz and D. Crisan Correlation of JAK2 V617F Mutant Allele Quantitation with Clinical Presentation and Type of Chronic Myeloproliferative Neoplasm Ann. Clin. Lab. Sci., January 1, 2009; 39(4): 345 - 350. [Abstract] [Full Text] [PDF] M. Marchetti, E. Castoldi, H. M. H. Spronk, R. van Oerle, D. Balducci, T. 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M. Mannucci and F. Peyvandi Thrombophilia Screening: Little Role for the JAK2V617F Mutation Mayo Clin. Proc., April 1, 2008; 83(4): 398 - 399. [Full Text] [PDF] R. Landolfi and L. Di Gennaro Prevention of thrombosis in polycythemia vera and essential thrombocythemia Haematologica, March 1, 2008; 93(3): 331 - 335. [Full Text] [PDF] V. De Stefano, T. Za, E. Rossi, A. M. Vannucchi, M. Ruggeri, E. Elli, C. Mico, A. Tieghi, R. R. Cacciola, C. Santoro, et al. Recurrent thrombosis in patients with polycythemia vera and essential thrombocythemia: incidence, risk factors, and effect of treatments Haematologica, March 1, 2008; 93(3): 372 - 380. [Abstract] [Full Text] [PDF] R. A. Mesa Steel to heal? MPD surgical conundrums Blood, January 15, 2008; 111(2): 474 - 474. [Full Text] [PDF] M. Ruggeri, F. Rodeghiero, A. Tosetto, G. Castaman, F. Scognamiglio, G. Finazzi, F. Delaini, C. Mico, A. M. Vannucchi, E. Antonioli, et al. 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