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Blood, 1 June 2007, Vol. 109, No. 11, pp. 4825-4931. Prepublished online as a Blood First Edition Paper on February 22, 2007; DOI 10.1182/blood-2006-08-043810. This Article Full Text (PDF) Supplemental Figures All Versions of this Article: blood-2006-08-043810v1 109/11/4825    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Welner, R. S. Articles by Kincade, P. W. Search for Related Content PubMed PubMed Citation Articles by Welner, R. S. Articles by Kincade, P. W. Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted August 25, 2006 Accepted February 11, 2007 Interferon-producing killer dendritic cells (IKDC) arise via a unique differentiation pathway from primitive c-kitHiCD62L+ lymphoid progenitors Robert S. Welner, Rosana Pelayo, Karla P. Garrett, Xinrong Chen, S. Scott Perry, Xiao-Hong Sun, Barbara L. Kee, and Paul W. Kincade* Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States Immunobiology and Cancer Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, United States Department of Pathology, University of Chicago, Chicago, IL, United States * Corresponding author; email: kincade{at}omrf.ouhsc.edu. Interferon-producing killer dendritic cells (IKDC) have only recently been described and they share some properties with plasmacytoid dendritic cells (pDC). We now show that they can arise from some of the same progenitors. However, IKDC expressed little or no RAG-1, Spi-B or TLR9, but responded to the TLR9 agonist CpG ODN by production of IFN. The RAG-1- pDC2 subset was more similar to IKDC than RAG-1+ pDC1 with respect to IFN production. The Id-2 transcriptional inhibitor was essential for production of IKDC and natural killer (NK) cells, but not pDC. IKDC developed from lymphoid progenitors in culture, but unlike pDC, were not affected by Notch receptor ligation. While IKDC could be made from estrogen sensitive progenitors, they may have a slow turnover because their numbers did not rapidly decline in hormone treated mice. Four categories of progenitors were compared for IKDC producing ability in transplantation assays. Of these, Lin-Sca-1+c-KitHiThy1.1- L-selectin+ lymphoid progenitors (LSP) were the best source. While NK cells resemble IKDC in several respects, they develop from different progenitors. These observations suggest that IKDC may arise from a unique differentiation pathway, and one that diverges early from those responsible for NK, pDC, T and B cells. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: M. Terme, G. Mignot, E. Ullrich, M. Bonmort, V. Minard-Colin, A. Jacquet, J. L. Schultze, G. Kroemer, C. Leclerc, N. Chaput, et al. The Dendritic Cell-like Functions of IFN-Producing Killer Dendritic Cells Reside in the CD11b+ Subset and Are Licensed by Tumor Cells Cancer Res., August 15, 2009; 69(16): 6590 - 6597. [Abstract] [Full Text] [PDF] M. Pletneva, H. Fan, J.-J. Park, V. Radojcic, C. Jie, Y. Yu, C. Chan, A. Redwood, D. Pardoll, and F. Housseau IFN-Producing Killer Dendritic Cells Are Antigen-Presenting Cells Endowed with T-Cell Cross-Priming Capacity Cancer Res., August 15, 2009; 69(16): 6607 - 6614. [Abstract] [Full Text] [PDF] N. Himoudi, M. Yan, G. Bouma, D. Morgenstern, R. 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