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Blood, 1 May 2007, Vol. 109, No. 9, pp. 4089-4096. Prepublished online as a Blood First Edition Paper on January 18, 2007; DOI 10.1182/blood-2006-08-043935. This Article Full Text (PDF) All Versions of this Article: blood-2006-08-043935v1 109/9/4089    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by van Bergen, C. Articles by Falkenburg, J. Search for Related Content PubMed PubMed Citation Articles by van Bergen, C. Articles by Falkenburg, J. Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted August 29, 2006 Accepted December 20, 2006 Multiple myeloma reactive T cells recognize an activation induced minor histocompatibility antigen encoded by the ATP dependent interferon responsive (ADIR) gene CAM van Bergen*, MGD Kester, I Jedema, MHM Heemskerk, SAP van Luxemburg-Heijs, FM Kloosterboer, WAF Marijt, AH de Ru, MR Schaafsma, R Willemze, PA van Veelen, and JHF Falkenburg Laboratory of Experimental Hematology, Dept of Hematology, Leiden University Medical Center, Leiden, Netherlands Dept of Immunohematology & Blood Transfusion, Centre for Medical Systems Biology, Leiden University Medical Center, Leiden, Netherlands Medisch Spectrum Twente, Enschede, Netherlands * Corresponding author; email: c.a.m.van_bergen{at}lumc.nl. Minor Histocompatibility antigens (mHag) play an important role in both graft versus tumor effects and graft-versus-host disease (GVHD) after allogeneic stem cell transplantation. We applied biochemical techniques and mass spectrometry to identify the peptide recognized by a dominant tumor reactive donor T-cell reactivity isolated from a transplanted patient with relapsed multiple myeloma entering complete remission after donor lymphocyte infusion. A frequently occurring single nucleotide polymorphism in the human ATP-dependent interferon responsive (ADIR) gene was found to encode the epitope we designated LB-ADIR-1F. Although gene expression could be found in cells from hematopoietic as well as non-hematopoietic tissues, the patient suffered from only mild acute GVHD in spite of high percentages of circulating LB-ADIR-1F specific T-cells. Differential recognition of non-hematopioetic cell types and resting hematopoietic cells as compared to activated B-cells, T-cells and tumor cells was demonstrated, illustrating variable LB-ADIR-1F expression dependending on the cellular activation state. In conclusion, the novel mHag LB-ADIR-1F may be a suitable target for cellular immunotherapy when applied under controlled circumstances. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: A. N. Stumpf, E. D. van der Meijden, C. A. M. van Bergen, R. Willemze, J. H. F. Falkenburg, and M. Griffioen Identification of 4 new HLA-DR-restricted minor histocompatibility antigens as hematopoietic targets in antitumor immunity Blood, October 22, 2009; 114(17): 3684 - 3692. [Abstract] [Full Text] [PDF] D. S. DeLuca, B. Eiz-Vesper, N. Ladas, B. A.-M. Khattab, and R. Blasczyk High-throughput minor histocompatibility antigen prediction Bioinformatics, September 15, 2009; 25(18): 2411 - 2417. [Abstract] [Full Text] [PDF] R. M. Spaapen, H. M. Lokhorst, K. van den Oudenalder, B. E. Otterud, H. Dolstra, M. F. Leppert, M. C. Minnema, A. C. Bloem, and T. Mutis Toward targeting B cell cancers with CD4+ CTLs: identification of a CD19-encoded minor histocompatibility antigen using a novel genome-wide analysis J. Exp. Med., November 24, 2008; 205(12): 2863 - 2872. [Abstract] [Full Text] [PDF] M. Griffioen, H.M. E. van Egmond, H. Barnby-Porritt, M. A.W.G. van der Hoorn, R. S. Hagedoorn, M. G.D. Kester, N. Schwabe, R. Willemze, J.H. F. Falkenburg, and M. H.M. Heemskerk Genetic engineering of virus-specific T cells with T-cell receptors recognizing minor histocompatibility antigens for clinical application Haematologica, October 1, 2008; 93(10): 1535 - 1543. [Abstract] [Full Text] [PDF] T. Kawase, Y. Nannya, H. Torikai, G. Yamamoto, M. Onizuka, S. Morishima, K. Tsujimura, K. Miyamura, Y. Kodera, Y. Morishima, et al. Identification of human minor histocompatibility antigens based on genetic association with highly parallel genotyping of pooled DNA Blood, March 15, 2008; 111(6): 3286 - 3294. [Abstract] [Full Text] [PDF] M. Griffioen, E. D. van der Meijden, E. H. Slager, M. W. Honders, C. E. Rutten, S. A. P. van Luxemburg-Heijs, P. A. von dem Borne, J. J. van Rood, R. Willemze, and J. H. F. Falkenburg Identification of phosphatidylinositol 4-kinase type II {beta} as HLA class II-restricted target in graft versus leukemia reactivity PNAS, March 11, 2008; 105(10): 3837 - 3842. [Abstract] [Full Text] [PDF]

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