SEARCH:   Advanced

Blood, 15 June 2007, Vol. 109, No. 12, pp. 5186-5190. Prepublished online as a Blood First Edition Paper on March 8, 2007; DOI 10.1182/blood-2006-08-044503. This Article Full Text (PDF) All Versions of this Article: blood-2006-08-044503v1 109/12/5186    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Abkowitz, J. L Articles by Chen, J. Search for Related Content PubMed PubMed Citation Articles by Abkowitz, J. L Articles by Chen, J. Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted August 31, 2006 Accepted March 5, 2007 Studies of c-Mpl function distinguish the replication of hematopoietic stem cells from the expansion of differentiating clones Janis L Abkowitz* and Jing Chen Division of Hematology Department of Medicine, University of Washington, Seattle, WA, United States * Corresponding author; email: janabk{at}u.washington.edu. Three properties define hematopoietic stem cells (HSC): their capacity for quiescence and long survival, their ability to self-renew, and their ability to give rise to a multi-lineage clone of differentiating and maturing blood cells. Although it is likely that different signals regulate these events, this has been difficult to dissect on a molecular level, since HSC division, their fate decisions, and the earliest differentiation events cannot be directly visualized. Our studies of c-Mpl, the cellular receptor for the cytokine, thrombopoietin, suggest that c-Mpl does not control HSC number as had been previously argued, but rather facilitates the early expansion of differentiating clones. These experiments provide a strategy to distinguish the actions of HSC from earliest progenitor cells in vivo and demonstrate that a selective growth advantage at a level distal to HSC can result in a profound effect on multilineage hematopoiesis. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: C. James, F. Mazurier, S. Dupont, R. Chaligne, I. Lamrissi-Garcia, M. Tulliez, E. Lippert, F.-X. Mahon, J.-M. Pasquet, G. Etienne, et al. The hematopoietic stem cell compartment of JAK2V617F-positive myeloproliferative disorders is a reflection of disease heterogeneity Blood, September 15, 2008; 112(6): 2429 - 2438. [Abstract] [Full Text] [PDF]

	Copyright © 2007 by American Society of Hematology         Online ISSN: 1528-0020