|
|
Blood, 1 April 2007, Vol. 109, No. 7, pp. 3076-3079.
Prepublished online as a Blood First Edition Paper on November 30, 2006; DOI 10.1182/blood-2006-09-045989.
 Previous Article | Next Article 
Submitted September 8, 2006
Accepted November 18, 2006
CD10(-)MUM1(+) follicular lymphoma lacks BCL2 translocation and shows characteristic biological and clinical features
Kennosuke Karube*, Ying Guo, Junji Suzumiya, Yasuo Sugita, Yuko Nomura, Kohei Yamamoto, Kei Shimizu, Shirou Yoshida, Hideki Komatani, Morishige Takeshita, Masahiro Kikuchi, Naoya Nakamura, Osamu Takasu, Fumiko Arakawa, Hiroyuki Tagawa, Masao Seto, and Koichi Ohshima
Department of Pathology, School of Medicine, Kurume University, Kurume, Japan
Department of Pathology, State Key Laboratory of Cancer Biology, Xijing Hospital, Fourth Military Medical University, Shannxi, China
Department of Internal Medicine, School of Medicine, Fukuoka University, Fukuoka, Japan
Department of Pediatrics, School of Medicine, Fukuoka University, Fukuoka, Japan
Department of Pathology, School of Medicine, Fukuoka University, Fukuoka, Japan
Department of Pathology, Tokai University School of Medicine, Isehara, Japan
Div of Molecular Medicine & Div of Hematology & Cell Therapy, Aichi Cancer Center Institute, Nagoya, Japan
* Corresponding author; email: karube1975{at}yahoo.co.jp.
CD10 and MUM1 are representative B cell differentiation markers. Follicular lymphoma (FL) is usually positive for CD10 and negative for MUM1. In this study, however, we compared 22 FL with peculiar phenotype; CD10(-)MUM1(+) with 119 typical CD10(+)MUM1(-) FL. All CD10(-)MUM1(+) FL cases exhibited follicular structure with follicular dendritic meshwork, and a high rate of somatic hypermutation and on-going mutation, similar to typical FL. However, CD10(-)MUM1(+) FL were encountered frequently in the elderly compared with CD10(+)MUM1(-) typical FL (67.0 vs 58.7 years, p<0.01), showed high grade (Grade 3A or 3B) morphology (91% vs 17%, p<0.00001), diffuse proliferation (59% vs 19%, p<0.0001), and lacked BCL2/IgH translocation (5% vs 92.5%, p<0.00001), which is the most characteristic aberration in FL, and 88% showed BCL6 gene abnormalities (translocation or amplification). Our results indicate that CD10(-)MUM1(+) FL is different from typical FL with respect to biological and clinical features.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
J. W. Sweetenham, B. Goldman, M. L. LeBlanc, J. R. Cook, R. R. Tubbs, O. W. Press, D. G. Maloney, R. I. Fisher, L. M. Rimsza, R. M. Braziel, et al.
Prognostic value of regulatory T cells, lymphoma-associated macrophages, and MUM-1 expression in follicular lymphoma treated before and after the introduction of monoclonal antibody therapy: a Southwest Oncology Group Study
Ann. Onc.,
October 29, 2009;
(2009)
mdp460v1.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Leich, I. Salaverria, S. Bea, A. Zettl, G. Wright, V. Moreno, R. D. Gascoyne, W.-C. Chan, R. M. Braziel, L. M. Rimsza, et al.
Follicular lymphomas with and without translocation t(14;18) differ in gene expression profiles and genetic alterations
Blood,
July 23, 2009;
114(4):
826 - 834.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Katzenberger, J. Kalla, E. Leich, H. Stocklein, E. Hartmann, S. Barnickel, S. Wessendorf, M. M. Ott, H. K. Muller-Hermelink, A. Rosenwald, et al.
A distinctive subtype of t(14;18)-negative nodal follicular non-Hodgkin lymphoma characterized by a predominantly diffuse growth pattern and deletions in the chromosomal region 1p36
Blood,
January 29, 2009;
113(5):
1053 - 1061.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. A. Johnson and R. D. Gascoyne
Gene expression signatures in follicular lymphoma: are they ready for the clinic?
Haematologica,
July 1, 2008;
93(7):
982 - 987.
[Full Text]
[PDF]
|
|
|
|
|
