SEARCH:   Advanced

Blood, 15 May 2007, Vol. 109, No. 10, pp. 4336-4342. Prepublished online as a Blood First Edition Paper on January 23, 2007; DOI 10.1182/blood-2006-09-046201. This Article Full Text (PDF) All Versions of this Article: blood-2006-09-046201v1 109/10/4336    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Liu, C. Articles by Zhang, H.-G. Search for Related Content PubMed PubMed Citation Articles by Liu, C. Articles by Zhang, H.-G. Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted September 12, 2006 Accepted January 14, 2007 Expansion of spleen myeloid suppressor cells represses NK cell cytotoxicity in tumor bearing host Cunren Liu, Shaohua Yu, John Kappes, Jianhua Wang, William E. Grizzle, Kurt R. Zinn, and Huang-Ge Zhang* Div of Clinical Immunology & Rheumatology, Dept of Medicine, University of Alabama at Birmingham, Birmingham, AL, United States Dept of Microbiology, University of Alabama at Birmingham, Birmingham, AL, United States Dept of Pathology, University of Alabama at Birmingham, Birmingham, AL, United States Dept of Radiation Oncology, University of Alabama at Birmingham, Birmingham, AL, United States Birmingham Veterans Administration Medical Center, Birmingham, AL, United States * Corresponding author; email: huang-ge.zhang{at}ccc.uab.edu. Tumor growth promotes the expansion of myeloid suppressor cells. An inverse correlation between natural killer (NK) cell activation and myeloid suppressor cell expansion in tumor-bearing patients and mice prompted us to investigate the role of myeloid suppressor cells in controlling NK antitumor cytotocixity. After adoptive transfer to naive recipients, CD11b+Gr-1+ myeloid suppressor cells (MSC) freshly isolated from spleens of tumor-bearing mice but not naive mice were able to inhibit NK cell cytotoxicity. An in vivo imaging analysis indicates that the removal of tumors resulted in a significant increased ability (P < 0.05) in NK cell cytotoxicity to eliminate injected YAC-1 cells from the lungs. FACS analysis of the composition of lung leucocytes further indicates that the removal of tumors also leads to the reduction of MSCs accumulated in the lung. These data suggest that MSCs suppress NK cell cytotoxicity. The inhibition of NK cell cytotoxicity is cell-cell contact dependent. Inhibition of perforin but not granzyme B production was responsible for myeloid suppressor cell-mediated inhibition of NK cytotoxicity. Western blot analyses further suggests that myeloid suppressor cells suppress IL-2 mediated NK cell cytotoxicity by affecting the activity of Stat5. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: D. Ilkovitch and D. M. Lopez The Liver Is a Site for Tumor-Induced Myeloid-Derived Suppressor Cell Accumulation and Immunosuppression Cancer Res., July 1, 2009; 69(13): 5514 - 5521. [Abstract] [Full Text] [PDF] S. K. Bunt, V. K. Clements, E. M. Hanson, P. Sinha, and S. Ostrand-Rosenberg Inflammation enhances myeloid-derived suppressor cell cross-talk by signaling through Toll-like receptor 4 J. Leukoc. Biol., June 1, 2009; 85(6): 996 - 1004. [Abstract] [Full Text] [PDF] D. Ilkovitch and D. M. Lopez Urokinase-mediated recruitment of myeloid-derived suppressor cells and their suppressive mechanisms are blocked by MUC1/sec Blood, May 7, 2009; 113(19): 4729 - 4739. [Abstract] [Full Text] [PDF] J. Oberlies, C. Watzl, T. Giese, C. Luckner, P. Kropf, I. Muller, A. D. Ho, and M. Munder Regulation of NK Cell Function by Human Granulocyte Arginase J. Immunol., May 1, 2009; 182(9): 5259 - 5267. [Abstract] [Full Text] [PDF] S. Ostrand-Rosenberg and P. Sinha Myeloid-Derived Suppressor Cells: Linking Inflammation and Cancer J. Immunol., April 15, 2009; 182(8): 4499 - 4506. [Abstract] [Full Text] [PDF] Y. Zhang, Q. Liu, M. Zhang, Y. Yu, X. Liu, and X. Cao Fas Signal Promotes Lung Cancer Growth by Recruiting Myeloid-Derived Suppressor Cells via Cancer Cell-Derived PGE2 J. Immunol., March 15, 2009; 182(6): 3801 - 3808. [Abstract] [Full Text] [PDF] H. Li, Y. Han, Q. Guo, M. Zhang, and X. Cao Cancer-Expanded Myeloid-Derived Suppressor Cells Induce Anergy of NK Cells through Membrane-Bound TGF-{beta}1 J. Immunol., January 1, 2009; 182(1): 240 - 249. [Abstract] [Full Text] [PDF] N. Nausch, I. E. Galani, E. Schlecker, and A. Cerwenka Mononuclear myeloid-derived "suppressor" cells express RAE-1 and activate natural killer cells Blood, November 15, 2008; 112(10): 4080 - 4089. [Abstract] [Full Text] [PDF] S. Watanabe, K. Deguchi, R. Zheng, H. Tamai, L.-x. Wang, P. A. Cohen, and S. Shu Tumor-Induced CD11b+Gr-1+ Myeloid Cells Suppress T Cell Sensitization in Tumor-Draining Lymph Nodes J. Immunol., September 1, 2008; 181(5): 3291 - 3300. [Abstract] [Full Text] [PDF] P. De Sarno, R. C. Axtell, C. Raman, K. A. Roth, D. R. Alessi, and R. S. Jope Lithium Prevents and Ameliorates Experimental Autoimmune Encephalomyelitis J. Immunol., July 1, 2008; 181(1): 338 - 345. [Abstract] [Full Text] [PDF] M. Kobayashi, T. Yoshida, D. Takeuchi, V. C. Jones, K. Shigematsu, D. N. Herndon, and F. Suzuki Gr-1+CD11b+ cells as an accelerator of sepsis stemming from Pseudomonas aeruginosa wound infection in thermally injured mice J. Leukoc. Biol., June 1, 2008; 83(6): 1354 - 1362. [Abstract] [Full Text] [PDF] S. K. Bunt, L. Yang, P. Sinha, V. K. Clements, J. Leips, and S. Ostrand-Rosenberg Reduced Inflammation in the Tumor Microenvironment Delays the Accumulation of Myeloid-Derived Suppressor Cells and Limits Tumor Progression Cancer Res., October 15, 2007; 67(20): 10019 - 10026. [Abstract] [Full Text] [PDF]

	Copyright © 2007 by American Society of Hematology         Online ISSN: 1528-0020