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Blood, 15 March 2007, Vol. 109, No. 6, pp. 2488-2495. Prepublished online as a Blood First Edition Paper on November 14, 2006; DOI 10.1182/blood-2006-09-047290. This Article Full Text (PDF) All Versions of this Article: blood-2006-09-047290v1 109/6/2488    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Mostbock, S. Articles by Sabzevari, H. Search for Related Content PubMed PubMed Citation Articles by Mostbock, S. Articles by Sabzevari, H. Related Collections Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted September 14, 2006 Accepted November 2, 2006 Acquisition of Antigen Presentasomes (APS), an MHC/costimulatory complex, is a check-point of memory T cell homeostasis Sven Mostbock, Marta Catalfamo, Yutaka Tagaya, Jeffrey Schlom*, and Helen Sabzevari Laboratory of Tumor Immunology and Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD Metabolism Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD * Corresponding author; email: js141c{at}nih.gov. Immunological memory is associated with the activation and expansion of antigen-specific T cells, followed by clonal deletion and survival of a small number of memory T cells. This study establishes that effector and rested memory T cells can acquire major histocompatibility complex (MHC) / CD80 molecules (Antigen Presentasome, APS) upon activation in vitro and after vaccination in vivo. We demonstrate for the first time that acquisition of APS by rested memory T cells is correlated with increased levels of apoptosis in vivo and upregulation of caspase 3, bcl-x, bak and bax in our in vitro studies. Moreover, our results demonstrate that memory T cells with acquired APS can indeed become cytotoxic T lymphocytes and kill other cells through perforin mediated lysis. In addition, they retained the production of interferon and Th2 type cytokines. The acquisition of APS by memory T cells might be an important check-point leading to the clonal deletion of the majority of effector T cells, possibly allowing the surviving cells to become long term memory cells by default. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: Memory T cells: death by acquisition Ralph A. Reisfeld Blood 2007 109: 2269-2270. [Full Text] [PDF] This article has been cited by other articles: C. S. Umeshappa, H. Huang, Y. Xie, Y. Wei, S. J. Mulligan, Y. Deng, and J. Xiang CD4+ Th-APC with Acquired Peptide/MHC Class I and II Complexes Stimulate Type 1 Helper CD4+ and Central Memory CD8+ T Cell Responses J. Immunol., January 1, 2009; 182(1): 193 - 206. [Abstract] [Full Text] [PDF] J. Helft, A. Jacquet, N. T. Joncker, I. Grandjean, G. Dorothee, A. Kissenpfennig, B. Malissen, P. Matzinger, and O. Lantz Antigen-specific T-T interactions regulate CD4 T-cell expansion Blood, August 15, 2008; 112(4): 1249 - 1258. [Abstract] [Full Text] [PDF]

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