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Blood, 1 June 2007, Vol. 109, No. 11, pp. 4882-4889. Prepublished online as a Blood First Edition Paper on January 23, 2007; DOI 10.1182/blood-2006-10-043463. This Article Full Text (PDF) All Versions of this Article: blood-2006-10-043463v1 109/11/4882    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Zhu, Y. Articles by Chen, L. Search for Related Content PubMed PubMed Citation Articles by Zhu, Y. Articles by Chen, L. Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted October 8, 2006 Accepted January 12, 2007 CD137 stimulation delivers an antigen-independent growth signal for T lymphocytes with memory phenotype Yuwen Zhu, Gefeng Zhu, Liqun Luo, Andrew S. Flies, and Lieping Chen* Dept of Dermatology, Dept of Oncology, and the Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, United States * Corresponding author; email: lchen42{at}jhmi.edu. CD137 has long been recognized as a costimulatory receptor for growth and functional maturation of recently activated T cells in the presence of T cell receptor signal. In this report, we present the fact that, in the absence of MHC and antigen, triggering of CD137 by an agonist monoclonal antibody induces vigorous growth of both CD8+ and CD4+ T cells with memory phenotype whereas it does not affect naive T cells. Moreover, T cells with memory phenotype accumulate progressively in transgenic mice over-expressing CD137 ligand. CD137-mediated proliferation of memory T cells is directly through CD137 on T cell and does not require IL-15 and IFN-. Our results define a new role of CD137 signal in the growth of memory T cells. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: S.-W. Lee, S. Salek-Ardakani, R. S. Mittler, and M. Croft Hypercostimulation through 4-1BB Distorts Homeostasis of Immune Cells J. Immunol., June 1, 2009; 182(11): 6753 - 6762. [Abstract] [Full Text] [PDF] E. S. Chen, J. Wahlstrom, Z. Song, M. H. Willett, M. Wiken, R. C. Yung, E. E. West, J. F. McDyer, Y. Zhang, A. Eklund, et al. T Cell Responses to Mycobacterial Catalase-Peroxidase Profile a Pathogenic Antigen in Systemic Sarcoidosis J. Immunol., December 15, 2008; 181(12): 8784 - 8796. [Abstract] [Full Text] [PDF] L. Sabbagh, G. Pulle, Y. Liu, E. N. Tsitsikov, and T. H. Watts ERK-Dependent Bim Modulation Downstream of the 4-1BB-TRAF1 Signaling Axis Is a Critical Mediator of CD8 T Cell Survival In Vivo J. Immunol., June 15, 2008; 180(12): 8093 - 8101. [Abstract] [Full Text] [PDF] E. C. P. Waller, N. McKinney, R. Hicks, A. J. Carmichael, J. G. P. Sissons, and M. R. Wills Differential costimulation through CD137 (4 1BB) restores proliferation of human virus-specific "effector memory" (CD28 CD45RAHI) CD8+ T cells Blood, December 15, 2007; 110(13): 4360 - 4366. [Abstract] [Full Text] [PDF]

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