Submitted October 11, 2006
Accepted July 23, 2007
hDectin-1 is involved in uptake and cross-presentation of cellular antigens
Markus M. Weck, Silke Appel, Daniela Werth, Christian Sinzger, Anita Bringmann, Frank Grunebach, and Peter Brossart*
Department of Internal Medicine II, Division of Oncology, Hematology, Immunology, Rheumatology & Pneumology, University of Tubingen, Tubingen, Germany
Institute of Medical Virology, University of Tubingen, Tubingen, Germany
* Corresponding author; email: peter.brossart{at}med.uni-tuebingen.de.
Human (h)Dectin-1 is a member of the C-type-lectin-like receptor family that was shown to be the major receptor for fungal beta-glucans and to play an important role in the cellular responses mediated by these carbohydrates. In this study, we demonstrate that hDectin-1 is involved in the uptake and cross-presentation of cellular antigens. Furthermore, activation of monocyte-derived dendritic cells (MDCs) with TLR3 ligand but not with TLR2 ligand or TLR7 ligand resulted in down-regulation of hDectin-1 expression and reduced phagocytosis of apoptotic tumor cells as well as presentation of pp65-derived T-cell epitopes upon engulfment of CMV-infected human foreskin fibroblasts.
