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Blood, 1 July 2007, Vol. 110, No. 1, pp. 393-400. Prepublished online as a Blood First Edition Paper on March 19, 2007; DOI 10.1182/blood-2006-10-051763. This Article Full Text (PDF) All Versions of this Article: blood-2006-10-051763v1 110/1/393    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Peng, G. Articles by Wahl, S. M Search for Related Content PubMed PubMed Citation Articles by Peng, G. Articles by Wahl, S. M Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted October 13, 2006 Accepted February 16, 2007 Myeloid differentiation and susceptibility to HIV-1 are linked to APOBEC3 expression Gang Peng, Teresa Greenwell-Wild, Salvador Nares, Wenwen Jin, Ke Jian Lei, Zoila G Rangel, Peter J Munson, and Sharon M Wahl* Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD Mathematical and Statistical Computing Laboratory, Div. of Computational Bioscience, Center for Information Technology, National Institutes of Health, Bethesda, MD * Corresponding author; email: smwahl{at}dir.nidcr.nih.gov. HIV-1 recognition by, interaction with and/or infection of CD4+CCR5+ tissue macrophages and dendritic cells(DC) play important roles in HIV-1 transmission and pathogenesis. By comparison, circulating CD4+CCR5+ monocytes appear relatively resistant to HIV-1, and a fundamental unresolved question involves deciphering restriction factors unique to this precursor population. Not only do monocytes, relative to macrophages, possess higher levels of the innate resistance factor, APOBEC3G, but we uncovered APOBEC3A, not previously associated with anti-HIV activity, as being critical in monocyte resistance. Inversely correlated with susceptibility, silencing of APOBEC3A renders monocytes vulnerable to HIV-1. Differences in promiscuity of monocytes, macrophages and DC can be defined, at least partly, by disparities in APOBEC expression, with implications for buffing up cellular defenses against HIV-1. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: A. Bergamaschi, A. David, E. Le Rouzic, S. Nisole, F. Barre-Sinoussi, and G. Pancino The CDK Inhibitor p21Cip1/WAF1 Is Induced by Fc{gamma}R Activation and Restricts the Replication of Human Immunodeficiency Virus Type 1 and Related Primate Lentiviruses in Human Macrophages J. Virol., December 1, 2009; 83(23): 12253 - 12265. [Abstract] [Full Text] [PDF] F. A. Koning, E. N. C. Newman, E.-Y. Kim, K. J. Kunstman, S. M. Wolinsky, and M. H. Malim Defining APOBEC3 Expression Patterns in Human Tissues and Hematopoietic Cell Subsets J. Virol., September 15, 2009; 83(18): 9474 - 9485. [Abstract] [Full Text] [PDF] T. Greenwell-Wild, N. Vazquez, W. Jin, Z. Rangel, P. J. Munson, and S. M. Wahl Interleukin-27 inhibition of HIV-1 involves an intermediate induction of type I interferon Blood, August 27, 2009; 114(9): 1864 - 1874. [Abstract] [Full Text] [PDF] Q. Li, A. J. Smith, T. W. Schacker, J. V. Carlis, L. Duan, C. S. Reilly, and A. T. Haase Microarray Analysis of Lymphatic Tissue Reveals Stage-Specific, Gene Expression Signatures in HIV-1 Infection J. Immunol., August 1, 2009; 183(3): 1975 - 1982. [Abstract] [Full Text] [PDF] X. Wang and W. Ho Response: Intracellular restriction factors contribute to susceptibility of monocytes/macrophages to HIV-1 infection Blood, May 14, 2009; 113(20): 5030 - 5031. [Full Text] [PDF] C. M. Okeoma, A. Low, W. Bailis, H. Y. Fan, B. M. Peterlin, and S. R. Ross Induction of APOBEC3 In Vivo Causes Increased Restriction of Retrovirus Infection J. Virol., April 15, 2009; 83(8): 3486 - 3495. [Abstract] [Full Text] [PDF] S. Nares, N. M. Moutsopoulos, N. Angelov, Z. G. Rangel, P. J. Munson, N. Sinha, and S. M. Wahl Rapid Myeloid Cell Transcriptional and Proteomic Responses to Periodontopathogenic Porphyromonas gingivalis Am. J. Pathol., April 1, 2009; 174(4): 1400 - 1414. [Abstract] [Full Text] [PDF] M. H Malim APOBEC proteins and intrinsic resistance to HIV-1 infection Phil Trans R Soc B, March 12, 2009; 364(1517): 675 - 687. [Abstract] [Full Text] [PDF] Y.-L. Chiu and W. C Greene APOBEC3G: an intracellular centurion Phil Trans R Soc B, March 12, 2009; 364(1517): 689 - 703. [Abstract] [Full Text] [PDF] A. K. Khatua, H. E. Taylor, J. E. K. Hildreth, and W. Popik Exosomes Packaging APOBEC3G Confer Human Immunodeficiency Virus Resistance to Recipient Cells J. Virol., January 15, 2009; 83(2): 512 - 521. [Abstract] [Full Text] [PDF] S. Trapp, N. R. Derby, R. Singer, A. Shaw, V. G. Williams, S. G. Turville, J. W. Bess Jr., J. D. Lifson, and M. Robbiani Double-Stranded RNA Analog Poly(I:C) Inhibits Human Immunodeficiency Virus Amplification in Dendritic Cells via Type I Interferon-Mediated Activation of APOBEC3G J. Virol., January 15, 2009; 83(2): 884 - 895. [Abstract] [Full Text] [PDF]

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