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Blood, 1 November 2007, Vol. 110, No. 9, pp. 3463-3471. Prepublished online as a Blood First Edition Paper on July 30, 2007; DOI 10.1182/blood-2006-10-054080. This Article Full Text (PDF) All Versions of this Article: blood-2006-10-054080v1 110/9/3463    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Tichelli, A. Articles by Gratwohl, A. Search for Related Content PubMed PubMed Citation Articles by Tichelli, A. Articles by Gratwohl, A. Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted October 24, 2006 Accepted July 16, 2007 Premature cardiovascular disease after allogeneic stem cell transplantation Andre Tichelli*, Christoph Bucher, Alicia Rovo, Georg Stussi, Martin Stern, Michael Paulussen, Jorg Halter, Sandrine Meyer-Monard, Dominik Heim, Dimitrios A Tsakiris, Barbara Biedermann, Jakob R Passweg, and Alois Gratwohl Division of Hematology, University Hospital, Basel, Switzerland Pediatric Hematolgy / Oncology, University Children's Hospital (UKBB), Basel, Switzerland Department of Research, University Hospital, Basel, Switzerland * Corresponding author; email: tichelli{at}datacomm.ch. We assessed incidence and risk factors of cardiovascular events in 265 patients undergoing allogeneic hematopoietic stem cell transplantation (HSCT) between 1980-2000 and who survived 2 years. Results were compared to a cohort of 145 patients treated during the same period with autologous HSCT. The median age of patients with allogeneic HSCT at last follow-up was 39 years, median follow-up was 9 years. Eighteen (6.8%) patients after allogeneic, and 3 (2.1%) patients after autologous HSCT experienced an arterial event. The cumulative incidence of first arterial event after allogeneic HSCT was 22.1% [95%CI, 12.0-40.9] at 25 years. The cumulative incidence 15 years after allogeneic HSCT was 7.5% as compared to 2.3% after autologous HSCT. Adjusting for age, risk of an arterial event was significantly higher after allogeneic HSCT (RR 6.92; P=0.0093). In multivariate analysis, allogeneic HSCT (RR: 14.5; P=0.003) and 2 of 4 cardiovascular risk factors (hypertension, dyslipidemia, diabetes, obesity) (RR: 12.4; P=0.02) were associated with a higher incidence of arterial events after HSCT. Thus, long term survivors after allogeneic HSCT are at high risk for premature arterial vascular disease. HSCT might favor the emergence of established risk factor, such as hypertension, diabetes and dyslipidemia. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: Cardiovascular Disease Following Stem-Cell Transplantation Journal Watch Oncology and Hematology, November 20, 2007; 2007(1120): 2 - 2. [Full Text]

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