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Blood, 15 July 2007, Vol. 110, No. 2, pp. 783-786. Prepublished online as a Blood First Edition Paper on March 29, 2007; DOI 10.1182/blood-2006-10-054510. This Article Full Text (PDF) Supplemental Figure All Versions of this Article: blood-2006-10-054510v1 110/2/783    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Borsotti, C. Articles by van den Brink, M. R. Search for Related Content PubMed PubMed Citation Articles by Borsotti, C. Articles by van den Brink, M. R. Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted October 27, 2006 Accepted March 19, 2007 Absence of donor T cell derived soluble TNF decreases graft-versus-host-disease without impairing graft-versus-tumor activity Chiara Borsotti, Anna RK Franklin, Sydney X Lu, Theo D Kim, Odette Marsinay Smith, David Suh, Chris G King, Andrew Chow, Chen Liu, Onder Alpdogan, and Marcel RM van den Brink* Departments of Medicine and Immunology, Memorial Sloan-Kettering Cancer Center, New York, NY, United States Department of Pathology, Immunology and Laboratory Medicine, University of Florida, College of Medicine, Gainesville, FL, United States * Corresponding author; email: vandenbm{at}mskcc.org. Tumor necrosis factor (TNF) plays an important role in graft-versus-host disease (GVHD) and graft-versus-tumor (GVT) after allogeneic bone marrow transplantation (allo-BMT). TNF can be expressed in a membrane-bound form (memTNF) and as a soluble (solTNF) molecule after being cleaved by the TNF- converting enzyme (TACE). To study the contribution of donor T cell-derived memTNF versus solTNF in GVHD and GVT, we used mice containing a non-cleavable allele in place of endogenous TNF (memTNF/) as donors in murine BMT models. Recipients of memTNF T cells developed significantly less GVHD than recipients of wild-type (wt) T cells. In contrast, GVT activity mediated by memTNF T cells remained intact, and alloreactive memTNF T cells showed no defects in proliferation, activation and cytotoxicity. These data suggest that suppressing the secretion of solTNF by donor T cells significantly decreases GVHD without impairing GVT activity. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: L. W. Kappel, G. L. Goldberg, C. G. King, D. Y. Suh, O. M. Smith, C. Ligh, A. M. Holland, J. Grubin, N. M. Mark, C. Liu, et al. IL-17 contributes to CD4-mediated graft-versus-host disease Blood, January 22, 2009; 113(4): 945 - 952. [Abstract] [Full Text] [PDF] T. Yi, D. Zhao, C.-L. Lin, C. Zhang, Y. Chen, I. Todorov, T. LeBon, F. Kandeel, S. Forman, and D. Zeng Absence of donor Th17 leads to augmented Th1 differentiation and exacerbated acute graft-versus-host disease Blood, September 1, 2008; 112(5): 2101 - 2110. [Abstract] [Full Text] [PDF] J. E. Levine, S. Paczesny, S. Mineishi, T. Braun, S. W. Choi, R. J. Hutchinson, D. Jones, Y. Khaled, C. L. Kitko, D. Bickley, et al. Etanercept plus methylprednisolone as initial therapy for acute graft-versus-host disease Blood, February 15, 2008; 111(4): 2470 - 2475. [Abstract] [Full Text] [PDF]

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