SEARCH:   Advanced

Blood, 1 June 2007, Vol. 109, No. 11, pp. 4952-4963. Prepublished online as a Blood First Edition Paper on February 6, 2007; DOI 10.1182/blood-2006-10-055145. This Article Full Text (PDF) Supplemental Tables and Figure All Versions of this Article: blood-2006-10-055145v1 109/11/4952    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by de Leval, L. Articles by Gaulard, P. Search for Related Content PubMed PubMed Citation Articles by de Leval, L. Articles by Gaulard, P. Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted October 30, 2006 Accepted January 31, 2007 The gene expression profile of nodal peripheral T-cell lymphoma demonstrates a molecular link between angioimmunoblastic T-cell lymphoma (AITL) and follicular helper T cells (TFH) Laurence de Leval*, David S Rickman, Caroline Thielen, Aurelien de Reynies, Yen-Lin Huang, Georges Delsol, Laurence Lamant, Karen Leroy, Josette Briere, Thierry Molina, Francoise Berger, Christian Gisselbrecht, Luc Xerri, and Philippe Gaulard Pathology, CHU Sart-Tilman, University of Liege, Liege, Belgium Ligue Contre le Cancer, Paris, France Inserm, Unite 617, Universite Paris 12, Faculte de medecine, Institut Mondor de medecine moleculaire, Creteil, France Pathology, CHU Purpan, Toulouse, France Inserm, Unite 617, Assistance Publique-Hopitaux de Paris, Groupe hospitalier Henri Mondor, Dept de Pathologie, & Institut Mondor de medecine moleculaire, Creteil, France Pathology, Hopital Saint-Louis, Paris, France Pathology, Hotel-Dieu, Paris, France Pathology, Centre Hospitalier Lyon Sud, Pierre Benite, France Hematology, Hopital Saint-Louis, Paris, France Pathology, Institut Paoli Calmettes, Marseille, France * Corresponding author; email: l.deleval{at}ulg.ac.be. The molecular alterations underlying the pathogenesis of angioimmunoblastic T-cell lymphoma (AITL) and peripheral T-cell lymphoma, unspecified (PTCL-u) are largely unknown. In order to characterize the ontogeny and molecular differences between both entities, a series of AITLs (n=18) and PTCLs-u (n=16) was analyzed using gene expression profiling. Unsupervised clustering correlated with the pathological classification and with CD30 expression in PTCL-u. The molecular profile of AITLs was characterized by a strong microenvironment imprint (overexpression of B-cell- and follicular dendritic cell-related genes, chemokines, and genes related to extracellular matrix and vascular biology), and overexpression of several genes characteristic of normal follicular helper T cells (TFH) (CXCL13, BCL6, PDCD1, CD40L, NFATC1). By gene set enrichment analysis, the AITL molecular signature was significantly enriched in published TFH-specific genes. The enrichment was higher for sorted AITL cells than for tissue samples. Overexpression of several TFH genes was validated by immunohistochemistry in AITLs. A few cases with molecular TFH-like features were identified among CD30- PTCLs-u. Our findings strongly support that TFH cells represent the normal counterpart of AITL, and suggest that the AITL spectrum may be wider than suspected, as a subset of CD30- PTCL-u may derive from or be related to AITL. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: B. Chetaille, F. Bertucci, P. Finetti, B. Esterni, A. Stamatoullas, J. M. Picquenot, M. C. Copin, F. Morschhauser, O. Casasnovas, T. Petrella, et al. Molecular profiling of classical Hodgkin lymphoma tissues uncovers variations in the tumor microenvironment and correlations with EBV infection and outcome Blood, March 19, 2009; 113(12): 2765 - 3775. [Abstract] [Full Text] [PDF] K. Miyazaki, M. Yamaguchi, H. Imai, T. Kobayashi, S. Tamaru, K. Nishii, M. Yuda, H. Shiku, and N. Katayama Gene expression profiling of peripheral T-cell lymphoma including {gamma}{delta} T-cell lymphoma Blood, January 29, 2009; 113(5): 1071 - 1074. [Abstract] [Full Text] [PDF] M. Nakagawa, A. Nakagawa-Oshiro, S. Karnan, H. Tagawa, A. Utsunomiya, S. Nakamura, I. Takeuchi, K. Ohshima, and M. Seto Array Comparative Genomic Hybridization Analysis of PTCL-U Reveals a Distinct Subgroup with Genetic Alterations Similar to Lymphoma-Type Adult T-Cell Leukemia/Lymphoma Clin. Cancer Res., January 1, 2009; 15(1): 30 - 38. [Abstract] [Full Text] [PDF] C Agostinelli, P P Piccaluga, P Went, M Rossi, A Gazzola, S Righi, T Sista, C Campidelli, P L Zinzani, B Falini, et al. Peripheral T cell lymphoma, not otherwise specified: the stuff of genes, dreams and therapies J. Clin. Pathol., November 1, 2008; 61(11): 1160 - 1167. [Abstract] [Full Text] [PDF] A. Carbone, A. Gloghini, and G. Dotti EBV-Associated Lymphoproliferative Disorders: Classification and Treatment Oncologist, May 1, 2008; 13(5): 577 - 585. [Abstract] [Full Text] [PDF] N. Mourad, N. Mounier, J. Briere, E. Raffoux, A. Delmer, A. Feller, C. J. L. M. Meijer, J.-F. Emile, R. Bouabdallah, A. Bosly, et al. Clinical, biologic, and pathologic features in 157 patients with angioimmunoblastic T-cell lymphoma treated within the Groupe d'Etude des Lymphomes de l'Adulte (GELA) trials Blood, May 1, 2008; 111(9): 4463 - 4470. [Abstract] [Full Text] [PDF] A. Tzankov, C. Meier, P. Hirschmann, P. Went, S. A. Pileri, and S. Dirnhofer Correlation of high numbers of intratumoral FOXP3+ regulatory T cells with improved survival in germinal center-like diffuse large B-cell lymphoma, follicular lymphoma and classical Hodgkin's lymphoma Haematologica, February 1, 2008; 93(2): 193 - 200. [Abstract] [Full Text] [PDF] L. de Leval and P. Gaulard Pathobiology and Molecular Profiling of Peripheral T-Cell Lymphomas Hematology, January 1, 2008; 2008(1): 272 - 279. [Abstract] [Full Text] [PDF] V. L. Bryant, C. S. Ma, D. T. Avery, Y. Li, K. L. Good, L. M. Corcoran, R. de Waal Malefyt, and S. G. Tangye Cytokine-Mediated Regulation of Human B Cell Differentiation into Ig-Secreting Cells: Predominant Role of IL-21 Produced by CXCR5+ T Follicular Helper Cells J. Immunol., December 15, 2007; 179(12): 8180 - 8190. [Abstract] [Full Text] [PDF] P. P. Piccaluga, C. Agostinelli, A. Califano, A. Carbone, L. Fantoni, S. Ferrari, A. Gazzola, A. Gloghini, S. Righi, M. Rossi, et al. Gene Expression Analysis of Angioimmunoblastic Lymphoma Indicates Derivation from T Follicular Helper Cells and Vascular Endothelial Growth Factor Deregulation Cancer Res., November 15, 2007; 67(22): 10703 - 10710. [Abstract] [Full Text] [PDF] M. Cuadros, E. Honrado, M. Zajac, J. Benitez, B. Martinez-Delgado, S. S. Dave, L. M. Staudt, E. S. Jaffe, R. Milne, J. Alves, et al. In Reply J. Clin. Oncol., October 20, 2007; 25(30): 4851 - 4852. [Full Text] [PDF]

	Copyright © 2007 by American Society of Hematology         Online ISSN: 1528-0020