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Blood, 15 September 2007, Vol. 110, No. 6, pp. 1756-1761. Prepublished online as a Blood First Edition Paper on May 25, 2007; DOI 10.1182/blood-2006-11-050526. This Article Full Text (PDF) Supplemental Appendix All Versions of this Article: blood-2006-11-050526v1 110/6/1756    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Teramura, M. Articles by Mizoguchi, H. Search for Related Content PubMed PubMed Citation Articles by Teramura, M. Articles by Mizoguchi, H. Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted November 28, 2006 Accepted May 9, 2007 Treatment of severe aplastic anemia with antithymocyte globulin and cyclosporin A with or without G-CSF in adults; a multicenter randomized study in Japan Masanao Teramura*, Akiro Kimura, Satsuki Iwase, Yuji Yonemura, Shinji Nakao, Akio Urabe, Mitsuhiro Omine, and Hideaki Mizoguchi Department of Hematology, Tokyo Women's Medical University, Tokyo, Japan Department of Hematology and Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan Department of Hematology/Oncology, Aoto Hospital, Tokyo, Japan Blood transfusion Service, Kumamoto University school of Medicine, Kumamoto, Japan Cellular Transplantation Biology, Division of Cancer Medicine, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan Division of Hematology, NTT Kanto Medical Center, Tokyo, Japan Division of Hematology, Internal Medicine, Showa University Fujigaoka Hospital, Yokohama, Japan * Corresponding author; email: teramura{at}dh.twmu.ac.jp. We report the results of a randomized study to elucidate whether addition of granulocyte colony-stimulating factor (G-CSF) to immunosuppressive therapy is valuable for the treatment of severe aplastic anemia (SAA) in adults. One hundred and one previously untreated patients (median age; 54, range; 19 to 75) were randomized to receive antithymocyte globulin (ATG) and cyclosporin A (CyA) (G-CSF- group) or ATG, CyA and G-CSF (G-CSF+ group). In the G-CSF+ group, the hematological response rate at 6 months was higher (77% vs 57%; P=.03) than in the G-CSF- group. No differences were observed between the groups in terms of the incidence of infections and febrile episodes. There were no differences between the G-CSF- group and the G-CSF+ group in terms of survival (88% vs 94% at 4 years), and the development of myelodysplastic syndrome (MDS)/acute leukemia (AL) (1 patient vs 2 patients). However, the relapse rate was lower in the G-CSF+ group compared with the G-CSF- group (42% vs 15% at 4 years; P=.01). Further follow-up is required to elucidate the role of G-CSF in immunosuppressive therapy for adult SAA. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: R. Gurion, A. Gafter-Gvili, M. Paul, L. Vidal, I. Ben-Bassat, M. Yeshurun, O. Shpilberg, and P. Raanani Hematopoietic growth factors in aplastic anemia patients treated with immunosuppressive therapy-systematic review and meta-analysis Haematologica, May 1, 2009; 94(5): 712 - 719. [Abstract] [Full Text] [PDF] Treatment of Aplastic Anemia Journal Watch Oncology and Hematology, October 16, 2007; 2007(1016): 5 - 5. [Full Text] A. Bacigalupo Aplastic Anemia: Pathogenesis and Treatment Hematology, January 1, 2007; 2007(1): 23 - 28. [Abstract] [Full Text] [PDF]

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