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Blood, 1 June 2007, Vol. 109, No. 11, pp. 4973-4979. Prepublished online as a Blood First Edition Paper on February 6, 2007; DOI 10.1182/blood-2006-11-054916. This Article Full Text (PDF) All Versions of this Article: blood-2006-11-054916v1 109/11/4973    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Josefsson, P. Articles by Buhl, A. M. Search for Related Content PubMed PubMed Citation Articles by Josefsson, P. Articles by Buhl, A. M. Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted November 6, 2006 Accepted January 31, 2007 CLLU1 expression analysis adds prognostic information to risk prediction in chronic lymphocytic leukemia Par Josefsson*, Christian H Geisler, Henrik Leffers, Jorgen H Petersen, Mette K Andersen, Jesper Jurlander, and Anne Mette Buhl The Leukemia Laboratory, Dept of Hematology, Rigshospitalet and University of Copenhagen, Copenhagen, Denmark University Dept of Growth and Reproduction, Rigshospitalet and University of Copenhagen, Copenhagen, Denmark Dept of Biostatistics, Rigshospitalet and University of Copenhagen, Copenhagen, Denmark Dept of Clinical Genetics, Rigshospitalet and University of Copenhagen, Copenhagen, Denmark * Corresponding author; email: par.josefsson{at}pc.dk. We recently identified a disease-specific gene CLLU1 in chronic lymphocytic leukemia (CLL), and also demonstrated that high CLLU1 expression levels predict poor clinical outcome. To validate this finding, we measured CLLU1 mRNA expression levels by real-time RT-PCR in 175 patients with CLL. Analyses of IgVH mutational status, ZAP-70 expression, CD38 expression and chromosomal aberrations were also performed. High levels of CLLU1 expression were associated with shorter overall survival (P = 0.0016), with a 7 % increase in risk of early death by each doubling of the CLLU1 expression level. Stratification for age at diagnosis demonstrated a strong prognostic significance of CLLU1 expression in patients younger than 70 years (P < 0.0001), but not in patients aged 70 or more (P = 0.61). The prognostic significance of IgVH mutational status and ZAP-70 expression had a similar age-dependent variation. Multivariate analysis in the younger age group showed that CLLU1 expression analysis added further prognostic information within all prognostic subgroups, with the exception of unmutated IgVH CLL patients. Only CLLU1 expression and IgVH mutational status had independent predictive power. Thus analysis of CLLU1 expression is highly applicable in risk prediction in CLL for patients of an age eligible for risk stratification. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: V. Gattei, P. Bulian, M. I. Del Principe, A. Zucchetto, L. Maurillo, F. Buccisano, R. Bomben, M. Dal-Bo, F. Luciano, F. M. Rossi, et al. Relevance of CD49d protein expression as overall survival and progressive disease prognosticator in chronic lymphocytic leukemia Blood, January 15, 2008; 111(2): 865 - 873. [Abstract] [Full Text] [PDF]

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