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Blood, 15 October 2007, Vol. 110, No. 8, pp. 2803-2810. Prepublished online as a Blood First Edition Paper on June 26, 2007; DOI 10.1182/blood-2006-11-055673.
Submitted November 2, 2006
Pediatrics Division of Stem Cell Transplantation, Stanford University, Stanford, CA, United States * Corresponding author; email: kw1{at}stanford.edu.
Graft-versus-host disease (GVHD) continues to be a serious complication that limits the success of allogeneic bone marrow transplantation (BMT). Using IL-7 deficient murine models, we have previously shown that IL-7 is necessary for the pathogenesis of GVHD. In the present study, we determined whether GVHD could be prevented by antibody-mediated blockade of IL-7 receptor
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