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Blood, 1 September 2007, Vol. 110, No. 5, pp. 1540-1549. Prepublished online as a Blood First Edition Paper on May 4, 2007; DOI 10.1182/blood-2006-11-056010. This Article Full Text (PDF) Supplemental Table and Figures All Versions of this Article: blood-2006-11-056010v1 110/5/1540    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Tas, S. W Articles by de Jong, E. C Search for Related Content PubMed PubMed Citation Articles by Tas, S. W Articles by de Jong, E. C Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted November 6, 2006 Accepted April 19, 2007 Non-canonical NF-B signaling in dendritic cells is required for indoleamine 2,3-dioxygenase (IDO) induction and immune regulation Sander W Tas, Margriet J Vervoordeldonk, Najat Hajji, Joost H.N. Schuitemaker, Koen F van der Sluijs, Michael J May, Sankar Ghosh, Martien L Kapsenberg, Paul P Tak*, and Esther C de Jong Div. of Clinical Immunology & Rheumatology, AMC/University of Amsterdam, Amsterdam, Netherlands Dept. of Cell Biology and Histology, AMC/University of Amsterdam, Amsterdam, Netherlands Dept. of Experimental Immunology, AMC/University of Amsterdam, Amsterdam, Netherlands School of Veterinary Medicine, Dept. of Animal Biology, University of Pennsylvania, Philadelphia, PA, United States Immunobiology Section, Yale University Medical School, New Haven, CT, United States * Corresponding author; email: p.p.tak{at}amc.uva.nl. Ligation of CD40 on dendritic cells (DC) induces early production of inflammatory mediators via canonical NF-B signaling, as well as late expression of the anti-inflammatory enzyme indoleamine 2,3-dioxygenase (IDO) via unknown signal transduction. By selective blocking of either the canonical NF-B pathway using the NEMO-binding domain peptide or the non-canonical NF-B pathway by small interfering RNA, we demonstrate that IDO expression requires non-canonical NF-B signaling. Also, non-canonical NF-B signaling down-regulates pro-inflammatory cytokine production in DC. In addition, selective activation of the non-canonical NF-B pathway results in non-inflammatory DC that suppress T cell activation and promote the development of T cells with regulatory properties. These findings reveal an important role of the non-canonical NF-B pathway in the regulation of immunity. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: Y. H. Kim, B. K. Choi, W. J. Kang, K. H. Kim, S. W. Kang, A. L. Mellor, D. H. Munn, and B. S. Kwon IFN-{gamma}-indoleamine-2,3 dioxygenase acts as a major suppressive factor in 4-1BB-mediated immune suppression in vivo J. Leukoc. Biol., May 1, 2009; 85(5): 817 - 825. [Abstract] [Full Text] [PDF] A. Curti, S. Trabanelli, V. Salvestrini, M. Baccarani, and R. M. Lemoli The role of indoleamine 2,3-dioxygenase in the induction of immune tolerance: focus on hematology Blood, March 12, 2009; 113(11): 2394 - 2401. [Abstract] [Full Text] [PDF] Y.-I. Jeong, S. W. Kim, I. D. Jung, J. S. Lee, J. H. Chang, C.-M. Lee, S. H. Chun, M.-S. Yoon, G. T. Kim, S. W. Ryu, et al. Curcumin Suppresses the Induction of Indoleamine 2,3-Dioxygenase by Blocking the Janus-activated Kinase-Protein Kinase C{delta}-STAT1 Signaling Pathway in Interferon-{gamma}-stimulated Murine Dendritic Cells J. Biol. Chem., February 6, 2009; 284(6): 3700 - 3708. [Abstract] [Full Text] [PDF] M.-C. Yen, C.-C. Lin, Y.-L. Chen, S.-S. Huang, H.-J. Yang, C.-P. Chang, H.-Y. Lei, and M.-D. Lai A Novel Cancer Therapy by Skin Delivery of Indoleamine 2,3-Dioxygenase siRNA Clin. Cancer Res., January 15, 2009; 15(2): 641 - 649. [Abstract] [Full Text] [PDF] C. Orabona, M. T. Pallotta, C. Volpi, F. Fallarino, C. Vacca, R. Bianchi, M. L. Belladonna, M. C. Fioretti, U. Grohmann, and P. Puccetti SOCS3 drives proteasomal degradation of indoleamine 2,3-dioxygenase (IDO) and antagonizes IDO-dependent tolerogenesis PNAS, December 30, 2008; 105(52): 20828 - 20833. [Abstract] [Full Text] [PDF] M. L. Belladonna, C. Volpi, R. Bianchi, C. Vacca, C. Orabona, M. T. Pallotta, L. Boon, S. Gizzi, M. C. Fioretti, U. Grohmann, et al. Cutting Edge: Autocrine TGF-{beta} Sustains Default Tolerogenesis by IDO-Competent Dendritic Cells J. Immunol., October 15, 2008; 181(8): 5194 - 5198. [Abstract] [Full Text] [PDF] W. Chen, X. Liang, A. J. Peterson, D. H. Munn, and B. R. Blazar The Indoleamine 2,3-Dioxygenase Pathway Is Essential for Human Plasmacytoid Dendritic Cell-Induced Adaptive T Regulatory Cell Generation J. Immunol., October 15, 2008; 181(8): 5396 - 5404. [Abstract] [Full Text] [PDF]

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