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Blood, 15 July 2007, Vol. 110, No. 2, pp. 568-577.
Prepublished online as a Blood First Edition Paper on March 19, 2007; DOI 10.1182/blood-2006-11-057125.
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Submitted November 9, 2006
Accepted March 14, 2007
HLA-G expression defines a novel regulatory T cell subset present in
human peripheral blood and sites of inflammation
Ute Feger, Eva Tolosa, Yu-Hwa Huang, Anne Waschbisch, Tilo Biedermann, Arthur Melms, and Heinz Wiendl*
Department of General Neurology, Hertie-Institute for Clinical Brain Research, Eberhard-Karls-University Tuebingen, Tuebingen, Germany
Department of Neurology, University of Wuerzburg, Julius-Maximilians-University Wuerzburg, Wuerzburg, Germany
Department of Dermatology, Eberhard-Karls-University Tuebingen, Tuebingen, Germany
* Corresponding author; email: heinz.wiendl{at}klinik.uni-wuerzburg.de.
Regulatory T cells can inhibit harmful immunopathological responses directed against self and foreign antigens and play a major role in controlling autoimmunity. Here we have identified and characterized a subpopulation of CD4 and CD8 T cells in human peripheral blood expressing the immune tolerizing molecule HLA-G. HLA-G-expressing T cells are hypoproliferative, CD25- and FOXP3-negative, and exhibit potent suppressive properties which are partially mediated by HLA-G. HLA-G positive (HLA-Gpos) T cells are found at low percentages among CD4 and CD8 single positive thymocytes, suggesting a thymic origin. The presence of HLA-Gpos T cells at sites of inflammation such as inflamed skeletal muscle in myositis or the cerebrospinal fluid of patients with acute neuroinflammatory disorders suggests an important function in modulating parenchymal inflammatory responses in vivo.
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