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Blood, 1 August 2007, Vol. 110, No. 3, pp. 908-912. Prepublished online as a Blood First Edition Paper on April 4, 2007; DOI 10.1182/blood-2006-11-057604. This Article Full Text (PDF) All Versions of this Article: blood-2006-11-057604v1 110/3/908    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Austin, H. Articles by Hooper, W C. Search for Related Content PubMed PubMed Citation Articles by Austin, H. Articles by Hooper, W C. Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted November 13, 2006 Accepted March 30, 2007 Sickle-cell trait and the risk of venous thromboembolism among African Americans Harland Austin*, Nigel S Key, Jane M Benson, Cathy Lally, Nicole F Dowling, Carolyn Whitsett, and W Craig Hooper Department of Epidemiology, Emory University, Rollins School of Public Health, Atlanta, GA Department of Medicine, University of North Carolina, Chapel Hill, NC Division of Hereditary Blood Disorders, CDC, Atlanta, GA Transfusion Medicine, Mount Sinai School of Medicine, New York, NY * Corresponding author; email: haustin{at}sph.emory.edu. Persons with sickle-cell disease have a chronically activated coagulation system and display hemostatic perturbations, but it is unknown whether or not they experience an increased risk of venous thromboembolism. We conducted a case-control study of venous thromboembolism that included 515 hospitalized African American cases and 555 African American controls obtained from medical clinics. All subjects were assayed for hemoglobin S and hemoglobin C genotypes. The prevalence of the S allele was 0.070 and 0.032 for cases and controls, respectively (P < 0.001). The odds that a case had sickle-cell trait was about twice that of a control, indicating that the risk of venous thromboembolism is increased about two-fold among African Americans with sickle-cell trait compared with those with the wild-type genotype (odds ratio = 1.8 with 95% CI: 1.2, 2.9). The odds ratio for pulmonary embolism and sickle-cell trait was higher, 3.9 (2.2, 6.9). The prevalence of sickle-cell disease also was increased among cases compared with controls. We conclude that sickle-cell trait is a risk factor for venous thromboembolism and that the proportion of venous thromboembolism among African Americans attributable to the mutation is about 7%. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: S. S. Adam, N. S. Key, and C. S. Greenberg D-dimer antigen: current concepts and future prospects Blood, March 26, 2009; 113(13): 2878 - 2887. [Abstract] [Full Text] [PDF] S. S. Adam, G. Zaher, M. Ibrahim, K. I Ataga, L. M. De Castro, and N. S. Key Markers of Coagulation Activation and Inflammation in Sickle Cell Disease and Sickle Cell Trait Blood (ASH Annual Meeting Abstracts), November 16, 2008; 112(11): 4813 - 4813. [Abstract] M. G. Beckman, S. E. Critchley, W. C. Hooper, A. M. Grant, and R. Kulkarni CDC Division of Blood Disorders: Public Health Research Activities in Venous Thromboembolism Arterioscler Thromb Vasc Biol, March 1, 2008; 28(3): 394 - 395. [Full Text] [PDF] Venous Thrombosis in Patients with Sickle Cell Trait Journal Watch Oncology and Hematology, August 21, 2007; 2007(821): 2 - 2. [Full Text] K. I. Ataga and N. S. Key Hypercoagulability in Sickle Cell Disease: New Approaches to an Old Problem Hematology, January 1, 2007; 2007(1): 91 - 96. [Abstract] [Full Text] [PDF]

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