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Blood, 1 October 2007, Vol. 110, No. 7, pp. 2565-2568. Prepublished online as a Blood First Edition Paper on July 9, 2007; DOI 10.1182/blood-2006-11-058800. This Article Full Text (PDF) Supplemental Methods and Figures All Versions of this Article: blood-2006-11-058800v1 110/7/2565    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Nakae, S. Articles by Galli, S. J Search for Related Content PubMed PubMed Citation Articles by Nakae, S. Articles by Galli, S. J Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted November 20, 2006 Accepted June 21, 2007 TIM-1 and TIM-3 enhancement of Th2 cytokine production by mast cells Susumu Nakae, Motoyasu Iikura, Hajime Suto, Hisaya Akiba, Dale T Umetsu, Rosemarie H DeKruyff, Hirohisa Saito, and Stephen J Galli* Department of Pathology, Stanford University School of Medicine, Stanford, CA, United States Atopy Research Center, Juntendo University, Tokyo, Japan Department of Immunology, Juntendo University, Tokyo, Japan Division of Immunology, Children's Hospital Boston, Harvard Medical School, Boston, MA, United States Department of Allergy & Immunology, National Research Institute for Child Health & Development, Tokyo, Japan * Corresponding author; email: sgalli{at}stanford.edu. Members of the T cell immunoglobulin- and mucin-domain-containing molecule (TIM) family have roles in T cell-mediated immune responses. TIM-1 and TIM-2 are predominantly expressed on Th2 cells, whereas TIM-3 is preferentially expressed on Th1 and Th17 cells. We found that TIM-1 and TIM-3, but neither TIM-2 nor TIM-4, were constitutively expressed on mouse peritoneal mast cells and bone-marrow-derived cultured mast cells (BMCMCs). After IgE+Ag stimulation, TIM-1 expression was downregulated on BMCMCs, whereas TIM-3 expression was upregulated. We also found that recombinant mouse TIM-4 (rmTIM-4), which is a ligand for TIM-1, as well as an anti-TIM-3 polyclonal Ab, can promote IL-4, IL-6 and IL-13 production without enhancing degranulation in BMCMCs stimulated with IgE+Ag. Moreover, the anti-TIM-3 Ab, but neither anti-TIM-1 Ab nor rmTIM-4, suppressed mast cell apoptosis. These observations suggest that TIM-1 and TIM-3 may be able to influence T cell-mediated immune responses in part through effects on mast cells. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: T. Niki, S. Tsutsui, S. Hirose, S. Aradono, Y. Sugimoto, K. Takeshita, N. Nishi, and M. Hirashima Galectin-9 Is a High Affinity IgE-binding Lectin with Anti-allergic Effect by Blocking IgE-Antigen Complex Formation J. Biol. Chem., November 20, 2009; 284(47): 32344 - 32352. [Abstract] [Full Text] [PDF]

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