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Blood, 1 July 2007, Vol. 110, No. 1, pp. 180-185. Prepublished online as a Blood First Edition Paper on February 8, 2007; DOI 10.1182/blood-2006-11-060087. This Article Full Text (PDF) Supplemental Figures All Versions of this Article: blood-2006-11-060087v1 110/1/180    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Tsushima, F. Articles by Chen, L. Search for Related Content PubMed PubMed Citation Articles by Tsushima, F. Articles by Chen, L. Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted November 29, 2006 Accepted February 2, 2007 Interaction between B7-H1 and PD-1 determines initiation and reversal of T-cell anergy Fumihiko Tsushima, Sheng Yao, Tahiro Shin, Andrew Flies, Sarah Flies, Haiying Xu, Koji Tamada, Drew M Pardoll, and Lieping Chen* Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, United States Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, United States * Corresponding author; email: lchen42{at}jhmi.edu. Although self-reactive T cell precursors can be eliminated upon recognition of self-antigen presented in thymus, this central tolerance process is often incomplete and additional mechanisms are required to prevent autoimmunity. Recent studies implicate that the interaction between B7-H1 and its receptor PD-1 on activated T cells plays an important role in the inhibition of T cell responses in peripheral organs. Here we show that, before their exit to the periphery, T cells in lymphoid organs rapidly up-regulate PD-1 upon tolerogen recognition. Ablation of the B7-H1 and PD-1 interaction when T cells are still in lymphoid organs prevents anergy. Furthermore, blockade of B7-H1 and PD-1 interaction could render anergic T cells responsive to antigen. Our results thus reveal previously unappreciated roles of B7-H1 and PD-1 Interaction in the control of initiation and reversion of T cell anergy. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: M. N. Rivas, K. Weatherly, M. Hazzan, B. Vokaer, S. Dremier, F. Gaudray, M. Goldman, I. Salmon, and M. Y. Braun Reviving Function in CD4+ T Cells Adapted to Persistent Systemic Antigen J. 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