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Blood, 1 September 2007, Vol. 110, No. 5, pp. 1681-1688. Prepublished online as a Blood First Edition Paper on May 14, 2007; DOI 10.1182/blood-2006-12-060343. This Article Full Text (PDF) All Versions of this Article: blood-2006-12-060343v1 110/5/1681    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Peck, A. J. Articles by Boeckh, M. Search for Related Content PubMed PubMed Citation Articles by Peck, A. J. Articles by Boeckh, M. Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted December 11, 2006 Accepted May 1, 2007 Respiratory virus infection among hematopoietic cell transplantation recipients: evidence for asymptomatic parainfluenza virus infection Angela J. Peck, Janet A. Englund, Jane Kuypers, Katherine A. Guthrie, Lawrence Corey, Rhoda Morrow, Robert C. Hackman, Anne Cent, and Michael Boeckh* Department of Pediatrics, Division of Infectious Diseases, Children's Hospital & Regional Medical Center, Seattle, WA, United States Division of Laboratory Medicine, University of Washington, Seattle, WA, United States Division of Clinical Statistics, Fred Hutchinson Cancer Research Center, Seattle, WA, United States Program in Infectious Diseases, Fred Hutchinson Cancer Research Center, Seattle, WA, United States Division of Pathology and Laboratory Medicine, Fred Hutchinson Cancer Research Center, Seattle, WA, United States * Corresponding author; email: mboeckh{at}fhcrc.org. The incidence of respiratory virus infection following hematopoietic cell transplantation (HCT) has likely been underestimated using conventional testing methods in symptomatic patients. This prospective study assessed viral infection episodes by testing weekly respiratory samples collected from HCT recipients, with and without symptoms reported by questionnaire, for 100 days after HCT. Samples were tested by culture and direct fluorescent antibody for respiratory syncytial virus (RSV), parainfluenza virus (PIV), and influenza A and B, and by quantitative RT-PCR for RSV, PIV, influenza A and B, and metapneumovirus (MPV). Of 122 patients, 30 (25%) had 32 infection episodes due to RSV (5), PIV (17), MPV (6), influenza (3), RSV and influenza (1). PIV, with a cumulative incidence estimate of 17.9%, was the only virus for which asymptomatic infection was detected. Lower virus copy number in patients with 0 or 1 symptom compared with 2 or more symptoms was found for all viruses in all patients (p<0.001), with PIV infection having a similar virus-specific comparison (p=0.004). Subclinical infection with PIV may help explain why infection control programs emphasizing symptoms are effective against RSV and influenza but often not against PIV. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: W. G. Nichols, A. J. Peck Campbell, and M. Boeckh Respiratory Viruses Other than Influenza Virus: Impact and Therapeutic Advances Clin. Microbiol. Rev., April 1, 2008; 21(2): 274 - 290. [Abstract] [Full Text] [PDF]

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