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Blood, 1 December 2007, Vol. 110, No. 12, pp. 3827-3832. Prepublished online as a Blood First Edition Paper on August 31, 2007; DOI 10.1182/blood-2006-12-061408. This Article Full Text (PDF) Supplemental Figure Erratum (v112,p1546) All Versions of this Article: blood-2006-12-061408v1 110/12/3827    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Piper, K. P Articles by Moss, P. A. Search for Related Content PubMed PubMed Citation Articles by Piper, K. P Articles by Moss, P. A. Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted December 7, 2006 Accepted August 7, 2007 CXCL10 - CXCR3 interactions play an important role in the pathogenesis of acute graft-versus-host disease in the skin following allogeneic stem cell transplantation Karen P Piper*, Claire Horlock, S John Curnow, Julie Arrazi, Sarah Nicholls, Premini Mahendra, Charles Craddock, and Paul AH Moss CRUK Institute for Cancer Studies, University of Birmingham, Birmingham, United Kingdom Institute for Biomedical Research, University of Birmingham, Birmingham, United Kingdom Bone Marrow Transplant Unit, University Hospital Birmingham NHS Trust, Birmingham, United Kingdom CRUK Institute for Cancer Studies, University of Birmingham, Birmingham * Corresponding author; email: k.p.piper{at}bham.ac.uk. Acute graft-versus-host disease (aGvHD) remains a serious complication following allogeneic stem cell transplantation (SCT) and is mediated by infiltration of alloreactive donor T cells into recipient tissue. Chemokines and their receptors play a central role in controlling the recruitment of T cells into discrete tissue sites and determine the clinical features of GvHD in murine models. In this study we have analysed the serum concentration of molecules which control leucocyte migration in serial samples from 34 patients following allogeneic SCT. The chemokine CXCL10 (IP-10) was significantly elevated (>2-fold) in serum at the time of aGvHD. As the ligand for CXCL10 is CXCR3, the number of CXCR3+ T cells was determined in peripheral blood but was not increased during episodes of GvHD. To investigate the role of chemokines in the recruitment of T cells to anatomical site of GvHD, skin biopsies were stained for CXCL10 and CXCR3 expression. CXCL10 expression was observed in the basal keratinocytes of the epidermis in patients with GvHD together with positive staining for CXCR3 on cells in dermal infiltrates. These findings indicate that CXCL10 plays a central role in the pathogenesis of skin aGvHD by the recruitment of CXCR3-positive T cells to the sites of inflammation. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: G. Socie and B. R. Blazar Acute graft-versus-host disease: from the bench to the bedside Blood, November 12, 2009; 114(20): 4327 - 4336. [Abstract] [Full Text] [PDF] M. A. Curran and J. P. Allison Tumor Vaccines Expressing Flt3 Ligand Synergize with CTLA-4 Blockade to Reject Preimplanted Tumors Cancer Res., October 1, 2009; 69(19): 7747 - 7755. [Abstract] [Full Text] [PDF] R. J. Bodnar, C. C. Yates, M. E. Rodgers, X. Du, and A. Wells IP-10 induces dissociation of newly formed blood vessels J. 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Ravn, and on behalf of TBNET Evaluating the potential of IP-10 and MCP-2 as biomarkers for the diagnosis of tuberculosis Eur. Respir. J., December 1, 2008; 32(6): 1607 - 1615. [Abstract] [Full Text] [PDF] S. He, Q. Cao, Y. Qiu, J. Mi, J. Z. Zhang, M. Jin, H. Ge, S. G. Emerson, Y. Zhang, and Y. Zhang A New Approach to the Blocking of Alloreactive T Cell-Mediated Graft-versus-Host Disease by In Vivo Administration of Anti-CXCR3 Neutralizing Antibody J. Immunol., December 1, 2008; 181(11): 7581 - 7592. [Abstract] [Full Text] [PDF] M. Mohty, R. M. Szydlo, A. S. M. Yong, J. F. Apperley, J. M. Goldman, and J. V. Melo Association between BMI-1 expression, acute graft-versus-host disease, and outcome following allogeneic stem cell transplantation from HLA-identical siblings in chronic myeloid leukemia Blood, September 1, 2008; 112(5): 2163 - 2166. [Abstract] [Full Text] [PDF]

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