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Blood, 15 October 2007, Vol. 110, No. 8, pp. 3078-3081. Prepublished online as a Blood First Edition Paper on July 6, 2007; DOI 10.1182/blood-2006-12-062984. This Article Full Text (PDF) Erratum (v110,p4197) All Versions of this Article: blood-2006-12-062984v1 110/8/3078    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Baumeister, S. H C Articles by Schakel, K. Search for Related Content PubMed PubMed Citation Articles by Baumeister, S. H C Articles by Schakel, K. Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted December 19, 2006 Accepted June 21, 2007 G-CSF mobilizes slanDC (6-sulfo LacNAc+ dendritic cells) with a high proinflammatory capacity Susanne H C Baumeister, Kristina Holig, Martin Bornhauser, Michael Meurer, E. Peter Rieber, and Knut Schakel* Institute of Immunology, Medical Faculty, Technische Universitat Dresden, Dresden, Germany Department of Internal Medicine, Medical Faculty, Technische Universitat Dresden, Dresden, Germany Department of Dermatology, Medical Faculty, Technische Universitat Dresden, Dresden, Germany * Corresponding author; email: knut.schaekel{at}tu-dresden.de. Donor dendritic cells (DC) play a pivotal role in the induction of immunity and tolerance after peripheral blood stem cell transplantation (PBSCT). Treatment of healthy donors with granulocyte-colony stimulating factor (G-CSF) increases the numbers of tolerogenic DC and T cells among mobilized blood leukocytes in the graft. SlanDC (6-sulfo LacNAc+ DC), a major source of IL-12 and TNF- in blood, have not been studied in this respect. Here, we demonstrate that slanDC (14.9x106/L to 64.0x106/L) are efficiently mobilized by G-CSF and retain their capacity to produce IL-12 and TNF- at high levels. Furthermore, G-CSF-mobilized slanDC programmed the differentiation of Th1 cells and displayed a particularly strong capacity to stimulate the proliferation of naive allogeneic T cells. Thus, slanDC transfused into recipients of allogeneic PBSCT are functionally fully capable and may be critical in supporting graft-versus-host disease as well as graft-versus-leukemia effects. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: R. Wehner, D. Wehrum, M. Bornhauser, S. Zhao, K. Schakel, M. P. Bachmann, U. Platzbecker, G. Ehninger, E. P. Rieber, and M. Schmitz Mesenchymal stem cells efficiently inhibit the proinflammatory properties of 6-sulfo LacNAc dendritic cells Haematologica, August 1, 2009; 94(8): 1151 - 1156. [Abstract] [Full Text] [PDF] G.-Y. Chen, K. Sakuma, and R. Kannagi Significance of NF-{kappa}B/GATA Axis in Tumor Necrosis Factor-{alpha}-induced Expression of 6-Sulfated Cell Recognition Glycans in Human T-lymphocytes J. Biol. Chem., December 12, 2008; 283(50): 34563 - 34570. [Abstract] [Full Text] [PDF]

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