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Blood, 15 May 2007, Vol. 109, No. 10, pp. 4328-4335.
Prepublished online as a Blood First Edition Paper on January 25, 2007; DOI 10.1182/blood-2006-12-064170.
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Submitted December 20, 2006
Accepted January 16, 2007
TCR dim lymphocytes define populations of circulating effector cells that migrate to inflamed tissues
Zhuoli Zhang, Claire L Gorman, Anna-Chiara Vermi, Claudia Monaco, Andrew Foey, Sally Owen, Parisa Amjadi, Alena Vallance, Catherine McClinton, Federica M. Marelli-Berg, Pia Isomaki, Andrew Russell, Francesco Dazzi, Timothy J Vyse, Fionula M Brennan, and Andrew P Cope*
The Kennedy Institute of Rheumatology Division, Imperial College, London, United Kingdom
Division of Medicine, Imperial College, London, United Kingdom
* Corresponding author; email: andrew.cope{at}imperial.ac.uk.
The T cell receptor zeta (TCR ) chain is a master sensor and regulator of lymphocyte responses. Loss of TCR expression has been documented in infectious, inflammatory and malignant diseases, suggesting that it may serve to limit T cell reactivity and effector responses at sites of tissue damage. These observations prompted us to explore the relationship between TCR expression and effector function in T cells. We report here that TCRdim lymphocytes are enriched for antigen experienced cells refractory to TCR-induced proliferation. Compared to their TCRbright counterparts, TCRdim cells share characteristics of differentiated effector T cells but utilise accessory pathways for transducing signals for inflammatory cytokine gene expression, and cell contact dependent pathways to activate monocytes. TCRdim T cells accumulate in inflamed tissues in vivo and have intrinsic migratory activity in vitro. Whilst blocking leucocyte trafficking with anti-TNF therapy in vivo is associated with the accumulation of TCRdim T cells in peripheral blood, this T cell subset retains the capacity to migrate in vitro. Taken together, the functional properties of TCRdim T cells make them promising cellular targets for the treatment of chronic inflammatory disease.
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