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Blood, 1 June 2007, Vol. 109, No. 11, pp. 4627-4634.
Prepublished online as a Blood First Edition Paper on February 8, 2007; DOI 10.1182/blood-2006-12-064345.
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Submitted December 21, 2006
Accepted February 5, 2007
The peritoneal micromilieu commits B cells to home
to body cavities and the small intestine
Simon Berberich, Reinhold Forster, and Oliver Pabst*
Institute of Immunology, Hannover Medical School, Hannover, Germany
* Corresponding author; email: pabst.oliver{at}mh-hannover.de.
The distinct combination of homing receptors such as selectins, chemokine receptors and integrins directs the migration of lymphocytes throughout the body. Upon activation lymphocytes irreversibly switch their set of homing receptors now guiding them to entirely different destinations. Here we report that exposure of naive B cells to the microenvironment of the peritoneal cavity modulates their migration propensities in the absence of antigenic stimulation. B1 and B2 cells isolated from the peritoneal cavity re-enter this compartment more efficiently compared to splenic follicular B cells. Moreover, when kept in the peritoneal cavity splenic follicular B cells gain such increased capability to re-enter this compartment. These altered migratory capacities are reflected by an up-regulation of the chemokine receptors CXCR4, CXCR5, and  7-integrin by the peritoneum-experienced splenic B cells among which CXCR5 is instrumental in directing B cells into the peritoneal cavity. Moreover, intraperitoneal transfer of plasma blasts favours their migration into the small intestine presumably before class switch recombination occurs, demonstrating that a re-configured transient migration pattern is not restricted to naïve cells. In conclusion, these data demonstrate a hitherto unrecognized role for tissue specific cues, altering the migratory capacity of B1, naïve B2 as well as antigen-experienced B2 cells.
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