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Blood, 15 August 2007, Vol. 110, No. 4, pp. 1178-1183. Prepublished online as a Blood First Edition Paper on April 17, 2007; DOI 10.1182/blood-2007-01-066043. This Article Full Text (PDF) Supplemental Appendix and Tables All Versions of this Article: blood-2007-01-066043v1 110/4/1178    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Galli, M. Articles by Barbui, T. Search for Related Content PubMed PubMed Citation Articles by Galli, M. Articles by Barbui, T. Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted January 5, 2007 Accepted April 3, 2007 Clinical significance of different antiphospholipid antibodies in the WAPS (Warfarin in the Anti- Phospholipid Syndrome) study Monica Galli*, Giovanna Borrelli, Eva Marie Jacobsen, Rosa Maria Marfisi, Guido Finazzi, Roberto Marchioli, Finn Georg Wisloff, Stefania Marziali, Olivier Morboeuf, and Tiziano Barbui Divisione di Ematologia, Ospedali Riuniti, Bergamo, Italy Laboratory of Epidemiology, Istituto "Mario Negri Sud", S. Maria Imbaro (CH), Italy Department of Hematology, Ulleval University Hospital, Oslo, Norway Clinical Reasearch, Diagnostica Stago, Asnieres Cedex, France * Corresponding author; email: monicagalli{at}virgilio.it. To assess the clinical significance of lupus anticoagulants (LA) and antiphospholipid antibodies (aPL) towards thrombosis and abortions, we measured them in 112 patients whose samples were available at enrolment in the WAPS study. ELISA and coagulation test values in the highest and lowest tertiles were compared. When considered separately, IgG antibodies to 2-glycoprotein I (a2GPI) and prothrombin (aPT) were associated with anamnestic arterial and venous thrombosis, respectively, and those to annexin AV (aAnAV) with abortions. IgM antibodies to protein S and the lupus ratio of the dilute prothrombin time were associated with prospective thrombosis. No other association for IgM antibodies was seen. LA-positive patients who carried a2GPI antibodies were at risk of anamnestic arterial and total thrombosis and aPT antibodies to that of anamnestic venous and total thrombosis. LA-positive patients who carried IgG a2GPI and aAnAV antibodies were at risk for both anamnestic abortion and prospective thrombosis. Overall, these data support the inclusion of a2GPI antibodies in and suggest the removal of anticardiolipin antibodies from the laboratory criteria of the antiphospholipid syndrome. They also suggest that the measurement of aPT and aAnAV antibodies is useful in some selected situations and that there is little role for IgM antibody detection. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: M. Y. Chan, F. Andreotti, and R. C. Becker Hypercoagulable States in Cardiovascular Disease Circulation, November 25, 2008; 118(22): 2286 - 2297. [Full Text] [PDF] M. M Patnaik, K. Wudhikarn, M. M Shroff, A. A Killeen, M. T. Reding, and R. S. Kasthuri Spectrum of Antiphospholipid Antibodies and Associated Thrombotic and Obstetric Events among Patients with Antiphospholipid Syndrome Blood (ASH Annual Meeting Abstracts), November 16, 2008; 112(11): 5343 - 5343. [Abstract] S. M. Nelson and I. A. Greer The potential role of heparin in assisted conception Hum. Reprod. Update, November 1, 2008; 14(6): 623 - 645. [Abstract] [Full Text] [PDF] R Forastiero and M Martinuzzo Prothrombotic mechanisms based on the impairment of fibrinolysis in the antiphospholipid syndrome Lupus, October 1, 2008; 17(10): 872 - 877. [Abstract] [PDF] I Giles, A Lambrianides, and A Rahman Examining the non-linear relationship between monoclonal antiphospholipid antibody sequence, structure and function Lupus, October 1, 2008; 17(10): 895 - 903. [Abstract] [PDF] M. Borrell, I. Tirado, J. Mateo, A. Oliver, A. Santamaria, and J. Fontcuberta IgM anti-protein S antibodies as a risk factor for venous thrombosis Haematologica, July 1, 2008; 93(7): 1115 - 1117. [Full Text] [PDF] A. Membre, D. Wahl, V. Latger-Cannard, J.-P. Max, P. Lacolley, T. Lecompte, and V. Regnault The effect of platelet activation on the hypercoagulability induced by murine monoclonal antiphospholipid antibodies Haematologica, April 1, 2008; 93(4): 566 - 573. [Abstract] [Full Text] [PDF] Diagnosing Antiphospholipid Antibody Syndrome Journal Watch Oncology and Hematology, September 11, 2007; 2007(911): 1 - 1. [Full Text]

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