Blood online
Home About Blood Authors Subscriptions Permission Advertising Public Access contact us
 

 
Advanced
Current Issue
First Edition
Future Articles
Archives
Submit to Blood
Search
American Society of Hematology
Meeting Abstracts
Email Alerts
 Blood, 1 August 2007, Vol. 110, No. 3, pp. 847-850.
Prepublished online as a Blood First Edition Paper on April 5, 2007; DOI 10.1182/blood-2007-01-067546.

This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
blood-2007-01-067546v1
110/3/847    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Right arrow Rights and Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kordasti, S. Y
Right arrow Articles by Mufti, G. J
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kordasti, S. Y
Right arrow Articles by Mufti, G. J
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

arrow to previous article Previous Article  |  Next Article next article arrow

Submitted January 10, 2007
Accepted April 2, 2007

CD4+CD25high Foxp3+ regulatory T-cells in Myelodysplastic Syndrome (MDS)

Shahram Y Kordasti, Wendy Ingram, Janet Hayden, David Darling, Linda Barber, Behdad Afzali, Giovanna Lombardi, Marcin W Wlodarski, Jaroslaw P Maciejewski, Farzin Farzaneh, and Ghulam J Mufti*

Dept of Haematological Medicine, King's College London, London, United Kingdom
Immunoregulation Laboratory, Dept of Nephrology and Transplantation, King's College London, London, United Kingdom
Experimental Hematology & Hematopoiesis Section, Cleveland Clinic Foundation, Cleveland, Ohio, United States

* Corresponding author; email: ghulam.mufti{at}kcl.ac.uk.

Foxp3+ regulatory T-cells (Treg) play a central role in maintaining immune tolerance. A reduction in the function of Tregs is a key feature of autoimmune diseases, whereas their expansion in malignant diseases leads to the suppression of host anti-tumor responses. We analyzed the absolute number of CD4+ and CD8+Tregs in the peripheral blood of 52 MDS patients and show a significant correlation between increased number of CD4+Tregs and MDS subgroups with ≥5% bone marrow blasts (p<0.001), high IPSS (p<0.001), and disease progression (p<0.001) whereas no correlation between CD8+Tregs and prognostic variables was observed. The CD4+Tregs showed a polyclonal spectratype and the percentage of the naive subset was significantly higher in the high risk patients compared to low risk or normal age matched donors (p=0.032). Our data suggests that CD4+Tregs expansion is a feature of high risk MDS and progression to aggressive subtypes of the disease.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 NEJMHome page
A. Tefferi and J. W. Vardiman
Myelodysplastic Syndromes
N. Engl. J. Med., November 5, 2009; 361(19): 1872 - 1885.
[Full Text] [PDF]

Home page
 Int ImmunolHome page
W. Wang, R. Lau, D. Yu, W. Zhu, A. Korman, and J. Weber
PD1 blockade reverses the suppression of melanoma antigen-specific CTL by CD4+CD25Hi regulatory T cells
Int. Immunol., September 1, 2009; 21(9): 1065 - 1077.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
I. Kotsianidis, E. Nakou, I. Bouchliou, A. Tzouvelekis, E. Spanoudakis, P. Steiropoulos, I. Sotiriou, V. Aidinis, D. Margaritis, C. Tsatalas, et al.
Global Impairment of CD4+CD25+FOXP3+ Regulatory T Cells in Idiopathic Pulmonary Fibrosis
Am. J. Respir. Crit. Care Med., June 15, 2009; 179(12): 1121 - 1130.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
D. Mougiakakos, C. C. Johansson, and R. Kiessling
Naturally occurring regulatory T cells show reduced sensitivity toward oxidative stress-induced cell death
Blood, April 9, 2009; 113(15): 3542 - 3545.
[Abstract] [Full Text] [PDF]

Home page
 haematolHome page
A. J. Barrett and E. Sloand
Autoimmune mechanisms in the pathophysiology of myelodysplastic syndromes and their clinical relevance
Haematologica, April 1, 2009; 94(4): 449 - 451.
[Full Text] [PDF]

Home page
 haematolHome page
M. E.D. Chamuleau, T. M. Westers, L. van Dreunen, J. Groenland, A. Zevenbergen, C. M. Eeltink, G. J. Ossenkoppele, and A. A. van de Loosdrecht
Immune mediated autologous cytotoxicity against hematopoietic precursor cells in patients with myelodysplastic syndrome
Haematologica, April 1, 2009; 94(4): 496 - 506.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
A. Curti, S. Trabanelli, V. Salvestrini, M. Baccarani, and R. M. Lemoli
The role of indoleamine 2,3-dioxygenase in the induction of immune tolerance: focus on hematology
Blood, March 12, 2009; 113(11): 2394 - 2401.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
S. Mittal, N. A. Marshall, L. Duncan, D. J. Culligan, R. N. Barker, and M. A. Vickers
Local and systemic induction of CD4+CD25+ regulatory T-cell population by non-Hodgkin lymphoma
Blood, June 1, 2008; 111(11): 5359 - 5370.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
X. Feng, S. Kajigaya, E. E. Solomou, K. Keyvanfar, X. Xu, N. Raghavachari, P. J. Munson, T. M. Herndon, J. Chen, and N. S. Young
Rabbit ATG but not horse ATG promotes expansion of functional CD4+CD25highFOXP3+ regulatory T cells in vitro
Blood, April 1, 2008; 111(7): 3675 - 3683.
[Abstract] [Full Text] [PDF]


click for free articles
home about blood authors subscriptions permissions advertising public access contact us
  Copyright © 2007 by American Society of Hematology         Online ISSN: 1528-0020