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 Blood, 15 August 2007, Vol. 110, No. 4, pp. 1215-1224.
Prepublished online as a Blood First Edition Paper on May 22, 2007; DOI 10.1182/blood-2007-01-068387.

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Submitted January 16, 2007
Accepted May 16, 2007

Splenic CD19-CD35+B220+ cells function as an inducer of the follicular dendritic cell-network formation

Takaya Murakami, Xin Chen, Koji Hase, Ayako Sakamoto, Chie Nishigaki, and Hiroshi Ohno*

Laboratory for Epithelial Immunology, RIKEN Research Center for Allergy and Immunology, Yokohama, Kanagawa, Japan
Laboratory of Molecular Immunoregulation, NCI-Frederick, Frederick, MD, United States
Supramolecular Biology, International Graduate School of Arts and Sciences, Yokohama City University, Yokohama, Kanagawa, Japan

* Corresponding author; email: ohno{at}rcai.riken.jp.

Follicular dendritic cells (FDCs) form a reticular FDC network in the lymphoid follicle, which is essential for the retention and presentation of native antigens in the form of antigen-antibody immune complexes (ICs) to B cells during secondary immune response. Although the presence of migrating precursors of FDCs has been hypothesized, their entity has not been elucidated. Here we report the identification of murine splenic CD19-CD11c-CD35+B220+ cells as an inducer of FDC network formation. We demonstrated that CD19-CD11c-CD35+B220+ cells, together with stromal cells, had the remarkable capability to form lymphoid-follicle-like structures that contained B220+FDC-M1+ reticular cells originally derived from CD19-CD11c-CD35+B220+ cells in the CD35+ reticulum. Our results indicate that CD19-CD11c-CD35+B220+ cells function as an inducer of FDC network formation, and that the interaction between CD19-CD11c-CD35+B220+ cells and stromal cells is required to initiate lymphoid follicle formation.


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