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Blood, 15 June 2007, Vol. 109, No. 12, pp. 5164-5167. Prepublished online as a Blood First Edition Paper on March 6, 2007; DOI 10.1182/blood-2007-01-069831. This Article Full Text (PDF) Supplemental Appendix, Table, and Figure All Versions of this Article: blood-2007-01-069831v1 109/12/5164    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Whitman, S. P Articles by Bloomfield, C. D. Search for Related Content PubMed PubMed Citation Articles by Whitman, S. P Articles by Bloomfield, C. D. Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted January 23, 2007 Accepted February 20, 2007 Long-term disease-free survivors with cytogenetically normal acute myeloid leukemia and MLL partial tandem duplication: a Cancer and Leukemia Group B study Susan P Whitman*, Amy S. Ruppert, Guido Marcucci, Krzysztof Mrozek, Peter Paschka, Christian Langer, Claudia D. Baldus, Jing Wen, Tamara Vukosavljevic, Bayard L. Powell, Andrew J. Carroll, Jonathan E. Kolitz, Richard A. Larson, Michael A. Caligiuri, and Clara D. Bloomfield Division of Hematology & Oncology, Dept of Internal Medicine, Comprehensive Cancer Center, Ohio State University, Columbus, OH, United States The Cancer and Leukemia Group B (CALGB) Statistical Center, Duke University Medical Center, Durham, NC, United States Division of Human Cancer Genetics, Dept of Microbiology, Virology, Immunology & Medical Genetics, Comprehensive Cancer Center, The Ohio State University, Columbus, OH, United States Charite, Campus Benjamin Franklin, Medizinische Klinik III, Berlin, Germany Section on Hematology and Oncology, Comprehensive Cancer Center of Wake Forest, Winston-Salem, NC, United States Division of Genetics, Internal Medicine, University of Alabama at Birmingham, Birmingham, AL, United States Internal Medicine, North Shore University Hospital, Manhasset, NY, United States Internal Medicine, University of Chicago, Chicago, IL, United States * Corresponding author; email: susan.whitman{at}osumc.edu. The clinical impact of MLL partial tandem duplication (MLL-PTD) was evaluated in 238 adults aged 18-59 years with cytogenetically normal (CN) de novo acute myeloid leukemia (AML) who were treated intensively on similar Cancer and Leukemia Group B protocols 9621 and 19808. Twenty-four (10.1%) patients harbored a MLL-PTD. Of those, 92% achieved complete remission (CR) compared with 83% of patients without MLL-PTD (P=.39). Neither overall survival nor disease-free survival significantly differed between the two groups (P=.67 and P=.55). Thirteen MLL-PTD+ patients relapsed within 1.4 years of achieving CR. MLL- PTD+ patients who relapsed more often had other adverse CN-AML-associated molecular markers. In contrast with previously reported studies, 9 (41%) MLL-PTD+ patients continue in long-term first remission (CR1; range, 2.5 to 7.7 years). Intensive consolidation therapy that included autologous peripheral stem-cell transplantation during CR1 may have contributed to the better outcome of this historically poor prognosis group of CN-AML patients with MLL-PTD. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: R. V. Tiu, L. P. Gondek, C. L. O'Keefe, J. Huh, M. A. Sekeres, P. Elson, M. A. McDevitt, X. F. Wang, M. J. Levis, J. E. Karp, et al. New Lesions Detected by Single Nucleotide Polymorphism Array-Based Chromosomal Analysis Have Important Clinical Impact in Acute Myeloid Leukemia J. Clin. Oncol., November 1, 2009; 27(31): 5219 - 5226. [Abstract] [Full Text] [PDF] C. Langer, G. Marcucci, K. B. Holland, M. D. Radmacher, K. Maharry, P. Paschka, S. P. Whitman, K. Mrozek, C. D. Baldus, R. Vij, et al. Prognostic Importance of MN1 Transcript Levels, and Biologic Insights From MN1-Associated Gene and MicroRNA Expression Signatures in Cytogenetically Normal Acute Myeloid Leukemia: A Cancer and Leukemia Group B Study J. Clin. Oncol., July 1, 2009; 27(19): 3198 - 3204. [Abstract] [Full Text] [PDF] G. Marcucci, K. Maharry, M. D. Radmacher, K. Mrozek, T. Vukosavljevic, P. Paschka, S. P. Whitman, C. Langer, C. D. Baldus, C.-G. Liu, et al. Prognostic Significance of, and Gene and MicroRNA Expression Signatures Associated With, CEBPA Mutations in Cytogenetically Normal Acute Myeloid Leukemia With High-Risk Molecular Features: A Cancer and Leukemia Group B Study J. Clin. Oncol., November 1, 2008; 26(31): 5078 - 5087. [Abstract] [Full Text] [PDF] S. P. Whitman, B. Hackanson, S. Liyanarachchi, S. Liu, L. J. Rush, K. Maharry, D. Margeson, R. Davuluri, J. Wen, T. Witte, et al. 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